Publications 2024
by date of publication in PubMed, most recent at the top:
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Publications
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Stereochemistry in the disorder-order continuum of protein interactions. Nature, 636(8043):762-768.
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DARPins as a novel tool to detect and degrade p73. Cell Death and Disease, 15(12):909.
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De novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder. The EMBO Journal, 44(2):413-436.
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On the specificity of the recognition of m6A-RNA by YTH reader domains. Journal of Biological Chemistry, 300(12):107998.
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Editorial: Modern approaches in cytoskeleton-related topics. Current Opinion in Cell Biology, 91:102423.
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Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture. PNAS Nexus, 3(12):pgae527.
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Biochemistry and genetics are coming together to improve our understanding of genotype to phenotype relationships. Current Opinion in Structural Biology, 89:102952.
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Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors. ACS Pharmacology & Translational Science, 7(12):4096-4111.
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Preparation of Polarity-Marked Microtubules Using a Plus-End Capping DARPin. Bio-protocol, 14(22):e5109.
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Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy. Scientific Reports, 14(1):27153.
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Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors. Protein Science, 33(11):e5191.
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Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96. ACS Chemical Biology, 19(10):2152-2164.
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CHARMM at 45: Enhancements in Accessibility, Functionality, and Speed. Journal of Physical Chemistry B, 128(41):9976-10042.
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Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements. Communications Biology, 7(1):1291.
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Experimental variables determine the outcome of RAS-RAS interactions. Journal of Biological Chemistry, 300(11):107859.
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Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity. JACS Au, 4(9):3466-3474.
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DARPin-fused T cell engager for adenovirus-mediated cancer therapy. Molecular therapy. Oncology, 32(3):200821.
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Targeted knock-in of NCF1 cDNA into the NCF2 locus leads to myeloid phenotypic correction of p47 $^{phox}$ -deficient chronic granulomatous disease. Molecular Therapy : Nucleic Acids, 35(3):102229.
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Hierarchical Protofilament Intertwining Rules the Formation of Mixed-Curvature Amyloid Polymorphs. Advanced Science, 11(32):e2402740.
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Engineering a Novel Probiotic Toolkit in Escherichia coli Nissle 1917 for Sensing and Mitigating Gut Inflammatory Diseases. ACS Synthetic Biology, 13(8):2376-2390.
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Intermediate filaments at a glance. Journal of Cell Science, 137(16):jcs261386.
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Structural determinants of intermediate filament mechanics. Current Opinion in Cell Biology, 89:102375.
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Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. Bioconjugate Chemistry, 35(7):922-933.
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Nanosecond chain dynamics of single-stranded nucleic acids. Nature Communications, 15(1):6010.
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Molecular mechanism of plasmid elimination by the DdmDE defense system. Science, 385(6705):188-194.
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HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing. Nature Communications, 15(1):5789.
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Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules. Proceedings of the National Academy of Sciences of the United States of America, 121(27):e2318198121.
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Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer. European Journal of Nuclear Medicine and Molecular Imaging, 51(8):2179-2192.
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A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2. Journal of Biological Chemistry, 300(7):107469.
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RNA-guided RNA silencing by an Asgard archaeal Argonaute. Nature Communications, 15(1):5499.
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mRNA Display Pipeline for Protein Biosensor Construction. ACS Sensors, 9(6):2846-2857.
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Structure-Based Design of a Potent and Selective YTHDC1 Ligand. Journal of Medicinal Chemistry, 67(11):9516-9535.
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Vimentin filaments integrate low-complexity domains in a complex helical structure. Nature Structural & Molecular Biology, 31(6):939-949.
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Small-Molecule Inhibitors of the m7G-RNA Writer METTL1. ACS Bio & Med Chem Au, 4(2):100-110.
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Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells. ACS Nano, 18(12):8919-8933.
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The catalytic mechanism of the RNA methyltransferase METTL3. eLife, 12:RP92537.
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Enhancing prime editor activity by directed protein evolution in yeast. Nature Communications, 15(1):2092.
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Gutless helper-dependent and first generation HAdV5 vectors have similar mechanical properties and common transduction mechanisms. Human Gene Therapy, 35(5-6):163-176.
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Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility. Nature Chemical Biology, 20(3):333-343.
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Past, present, and future of CRISPR genome editing technologies. Cell, 187(5):1076-1100.
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Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA. Nucleic Acids Research, 52(4):2012-2029.
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Proteolysis Targeting Chimera Degraders of the METTL3-14 m$^{6}$A-RNA Methyltransferase. JACS Au, 4(2):713-729.
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An alpha-helical lid guides the target DNA toward catalysis in CRISPR-Cas12a. Nature Communications, 15(1):1473.
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Identification of a Novel Subtype-Selective α$_{1B}$-Adrenoceptor Antagonist. ACS Chemical Neuroscience, 15(3):671-684.
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Single-Molecule FRET at 10 MHz Count Rates. Journal of the American Chemical Society, 146(5):3539-3544.
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Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate. Journal of the American Chemical Society, 146(3):1957-1966.
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Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Research, 52(1):462-473.