Master Theses

We offer Master thesis projects in computational as well as experimental Biochemistry surrounding the development and validation of small-molecule probes to study proteins involved in epitranscriptomics.

In a computational Master Thesis students will carry out a virtual screening campaign for epitranscriptomic targets (docking, MD simulations) and/or develop code (e.g., analysis scripts in Python or R).

An experimental Thesis in our group would involve cloning, expression and purification of a protein of interest and binding assays to screen potential ligands (for example by TR-FRET or Fluorescence Anisotropy spectroscopy). Depending on the project and interests of the student, the project could also include testing the activity of small-molecule probes in mammalian cancer cell lines or structure determination of a protein-ligand complex.

If you are interested in joining our interdisciplinary group for a Master Thesis, please contact Prof. A. Caflisch (caflisch@bioc.uzh.ch).