Publications of the Dutzler Group

ZORA Publication List

Publications

• 2024

  • Quinodoz, Mathieu; Rutz, Sonja; Peter, Virginie; Garavelli, Livia; Innes, A Micheil; Lehmann, Elena F; Kellenberger, Stephan; Peng, Zhong; Barone, Angelica; Campos-Xavier, Belinda; Unger, Sheila; Rivolta, Carlo; Dutzler, Raimund; Superti-Furga, Andrea (2024). De novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder. The EMBO Journal:Epub ahead of print.
  • Drożdżyk, Katarzyna; Peter, Martina; Dutzler, Raimund (2024). Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs. eLife, 13:RP96138.

• 2023

  • Lam, Andy Km; Dutzler, Raimund (2023). Mechanistic basis of ligand efficacy in the calcium-activated chloride channel TMEM16A. The EMBO Journal, 42(24):e115030.
  • Tippett, David N; Breen, Colum; Butler, Stephen J; Sawicka, Marta; Dutzler, Raimund (2023). Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange. eLife, 12:RP87178.
  • Ramanadane, Karthik; Liziczai, Márton; Markovic, Dragana; Straub, Monique S; Rosalen, Gian T; Udovcic, Anto; Dutzler, Raimund; Manatschal, Cristina (2023). Structural and functional properties of a plant NRAMP-related aluminum transporter. eLife, 12:e85641.
  • Lehmann, Elena Farah; Liziczai, Márton; Drożdżyk, Katarzyna; Altermatt, Patrick; Langini, Cassiano; Manolova, Vania; Sundstrom, Hanna; Dürrenberger, Franz; Dutzler, Raimund; Manatschal, Cristina (2023). Structures of ferroportin in complex with its specific inhibitor vamifeport. eLife, 12:e83053.
  • Rutz, Sonja; Deneka, Dawid; Dittmann, Antje; Sawicka, Marta; Dutzler, Raimund (2023). Structure of a volume-regulated heteromeric LRRC8A/C channel. Nature Structural & Molecular Biology, 30(1):52-61.

• 2022

  • Arndt, Melanie; Alvadia, Carolina; Straub, Monique S; Clerico Mosina, Vanessa; Paulino, Cristina; Dutzler, Raimund (2022). Structural basis for the activation of the lipid scramblase TMEM16F. Nature Communications, 13(1):6692.
  • Sawicka, Marta; Dutzler, Raimund (2022). Regulators of cell volume: The structural and functional properties of anion channels of the LRRC8 family. Current Opinion in Structural Biology, 74:102382.
  • Lam, Andy K M; Rutz, Sonja; Dutzler, Raimund (2022). Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC. Nature Communications, 13:2798.
  • Ramanadane, Karthik; Straub, Monique S; Dutzler, Raimund; Manatschal, Cristina (2022). Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family. eLife, 11:e74589.

• 2021

  • Deneka, Dawid; Rutz, Sonja; Hutter, Cedric A J; Seeger, Markus A; Sawicka, Marta; Dutzler, Raimund (2021). Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains. Nature Communications, 12:5435.
  • Sukalskaia, Anastasiia; Straub, Monique S; Deneka, Dawid; Sawicka, Marta; Dutzler, Raimund (2021). Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions. Nature Communications, 12:4893.
  • Straub, Monique S; Alvadia, Carolina; Sawicka, Marta; Dutzler, Raimund (2021). Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling. eLife, 10:e69800.
  • Lam, Andy K M; Dutzler, Raimund (2021). Mechanism of pore opening in the calcium-activated chloride channel TMEM16A. Nature Communications, 12:786.
  • Lam, Andy K M; Rheinberger, Jan; Paulino, Cristina; Dutzler, Raimund (2021). Gating the pore of the calcium-activated chloride channel TMEM16A. Nature Communications, 12:785.

• 2020

  • Drożdżyk, Katarzyna; Sawicka, Marta; Bahamonde-Santos, Maria-Isabel; Jonas, Zaugg; Deneka, Dawid; Albrecht, Christiane; Dutzler, Raimund (2020). Cryo-EM structures and functional properties of CALHM channels of the human placenta. eLife, 9:e55853.
  • Quesada, Roberto; Dutzler, Raimund (2020). Alternative chloride transport pathways as pharmacological targets for the treatment of cystic fibrosis. Journal of Cystic Fibrosis, 19 Suppl:S37-S41.

• 2019

  • Manatschal, Cristina; Pujol-Giménez, Jonai; Poirier, Marion; Reymond, Jean-Louis; Hediger, Matthias A; Dutzler, Raimund (2019). Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds. eLife, 8:e51913.
  • Walter, Justin D; Sawicka, Marta; Dutzler, Raimund (2019). Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport. eLife, 8:e46986.
  • Kalienkova, Valeria; Clerico Mosina, Vanessa; Bryner, Laura; Oostergetel, Gert T; Dutzler, Raimund; Paulino, Cristina (2019). Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. eLife, 8:e44364.
  • Alvadia, Carolina; Lim, Novandy K; Clerico Mosina, Vanessa; Oostergetel, Gert T; Dutzler, Raimund; Paulino, Cristina (2019). Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. eLife, 8:e44365.

Pagination