Publications of the Dutzler Group

ZORA Publication List

Publications

• 2025

  • Arndt, M., Schweri, A., & Dutzler, R. (2025). Structural basis for lipid transport at membrane contact sites by the IST2-OSH6 complex Nature Structural & Molecular Biology, 32, 2219–2230. https://doi.org/10.1038/s41594-025-01660-z
  • Sukalskaia, A., Karner, A., Pugnetti, A., Weber, F., Plochberger, B., & Dutzler, R. (2025). Interactions between TTYH2 and APOE facilitate endosomal lipid transfer Nature, 644, 273–279. https://doi.org/10.1038/s41586-025-09200-x
  • Liziczai, M., Fuchs, A., Manatschal, C., & Dutzler, R. (2025). Structural basis for metal ion transport by the human SLC11 proteins DMT1 and NRAMP1 Nature Communications, 16, 761. https://doi.org/10.1038/s41467-024-54705-0

• 2024

  • Quinodoz, M., Rutz, S., Peter, V., Garavelli, L., Innes, A. M., Lehmann, E. F., Kellenberger, S., Peng, Z., Barone, A., Campos-Xavier, B., Unger, S., Rivolta, C., Dutzler, R., & Superti-Furga, A. (2024). De novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder The EMBO Journal, 44, 413–436. https://doi.org/10.1038/s44318-024-00322-y
  • Drożdżyk, K., Peter, M., & Dutzler, R. (2024). Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs ELife, 13, RP96138. https://doi.org/10.7554/eLife.96138

• 2023

  • Lam, A. K., & Dutzler, R. (2023). Mechanistic basis of ligand efficacy in the calcium-activated chloride channel TMEM16A The EMBO Journal, 42, e115030. https://doi.org/10.15252/embj.2023115030
  • Tippett, D. N., Breen, C., Butler, S. J., Sawicka, M., & Dutzler, R. (2023). Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange ELife, 12, RP87178. https://doi.org/10.7554/eLife.87178
  • Ramanadane, K., Liziczai, M., Markovic, D., Straub, M. S., Rosalen, G. T., Udovcic, A., Dutzler, R., & Manatschal, C. (2023). Structural and functional properties of a plant NRAMP-related aluminum transporter ELife, 12, e85641. https://doi.org/10.7554/eLife.85641
  • Lehmann, E. F., Liziczai, M., Drożdżyk, K., Altermatt, P., Langini, C., Manolova, V., Sundstrom, H., Dürrenberger, F., Dutzler, R., & Manatschal, C. (2023). Structures of ferroportin in complex with its specific inhibitor vamifeport ELife, 12, e83053. https://doi.org/10.7554/eLife.83053
  • Rutz, S., Deneka, D., Dittmann, A., Sawicka, M., & Dutzler, R. (2023). Structure of a volume-regulated heteromeric LRRC8A/C channel Nature Structural & Molecular Biology, 30, 52–61. https://doi.org/10.1038/s41594-022-00899-0

• 2022

  • Arndt, M., Alvadia, C., Straub, M. S., Clerico Mosina, V., Paulino, C., & Dutzler, R. (2022). Structural basis for the activation of the lipid scramblase TMEM16F Nature Communications, 13, 6692. https://doi.org/10.1038/s41467-022-34497-x
  • Sawicka, M., & Dutzler, R. (2022). Regulators of cell volume: The structural and functional properties of anion channels of the LRRC8 family Current Opinion in Structural Biology, 74, 102382. https://doi.org/10.1016/j.sbi.2022.102382
  • Lam, A. K. M., Rutz, S., & Dutzler, R. (2022). Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC Nature Communications, 13, 2798. https://doi.org/10.1038/s41467-022-30479-1
  • Ramanadane, K., Straub, M. S., Dutzler, R., & Manatschal, C. (2022). Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family ELife, 11, e74589. https://doi.org/10.7554/eLife.74589

• 2021

  • Deneka, D., Rutz, S., Hutter, C. A. J., Seeger, M. A., Sawicka, M., & Dutzler, R. (2021). Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains Nature Communications, 12, 5435. https://doi.org/10.1038/s41467-021-25742-w
  • Sukalskaia, A., Straub, M. S., Deneka, D., Sawicka, M., & Dutzler, R. (2021). Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions Nature Communications, 12, 4893. https://doi.org/10.1038/s41467-021-25106-4
  • Straub, M. S., Alvadia, C., Sawicka, M., & Dutzler, R. (2021). Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling ELife, 10, e69800. https://doi.org/10.7554/eLife.69800
  • Lam, A. K. M., & Dutzler, R. (2021). Mechanism of pore opening in the calcium-activated chloride channel TMEM16A Nature Communications, 12, 786. https://doi.org/10.1038/s41467-020-20788-8
  • Lam, A. K. M., Rheinberger, J., Paulino, C., & Dutzler, R. (2021). Gating the pore of the calcium-activated chloride channel TMEM16A Nature Communications, 12, 785. https://doi.org/10.1038/s41467-020-20787-9

• 2020

  • Drożdżyk, K., Sawicka, M., Bahamonde-Santos, M.-I., Jonas, Z., Deneka, D., Albrecht, C., & Dutzler, R. (2020). Cryo-EM structures and functional properties of CALHM channels of the human placenta ELife, 9, e55853. https://doi.org/10.7554/eLife.55853

Pagination