Publications of the Sonderegger Group

Sonderegger, P. & Matsumoto-Miyai, K. Activity-controlled proteolytic cleavage at the synapse. Trends Neurosci. 37, 413-23 (2014). PMID: 24969462.

Ster, J., Steuble, M., Orlando, C., Diep, TM., Akhmedov, A., Raineteau, O., Pernet, V., Sonderegger, P. & Gerber, U. Calsyntenin-1 regulates targeting of dendritic NMDA receptors and dendritic spine maturation in CA1 hippocampal pyramidal cells during postnatal development. J. Neurosci. 34, 8716-27 (2014). PMID: 24966372.

Gisler, C., Lüscher, D., Schätzle, P., Dürr, S., Baici, A., Gallicotti, G., Reif, R., Bolliger, MF., Kunz, B. & Sonderegger, P. Zymogen activation of neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans. Biochem J. 453, 83-100 (2013).

Schätzle, P., Wuttke, R., Ziegler, U. & Sonderegger, P. Automated quantification of synapses by fluorescence microscopy. J. Neurosci. Methods 204, 144-149 (2012).

Steuble, M., Diep, TM., Schätzle, P., Ludwig, A., Tagaya, M., Kunz, B. & Sonderegger, P. Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport. Biol Open. 1, 761-774 (2012). 

Bütikofer, L. Zurlinden , A., Bolliger, MF., Kunz, B. & Sonderegger, P. Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia. FASEB J. 12, 4378-4393 (2011).

Schätzle, P., Ster J., Verbich, D., Mc Kinney, RA., Gerber, U., Sonderegger, P. & Mateos, JM. Rapid and reversible formation of spine head filopodia in response to muscarinic receptor activation in CA 1 pyramidal cells. J Physiol. 589, 4353-4364 (2011). 

Bányai L, Sonderegger P & Patthy L. Agrin binds BMP2, BMP4 and TGFbeta1. PLoS One. 5(5):e10758 (2010).

Bolliger, MF., Zurlinden, A., Lüscher, D., Bütikofer, L., Shakhova, O., Francolini, M., Kozlov, SV., Cinelli, P., Stephan, A., Kistler, AD., Rülicke, T., Pelczar, P., Ledermann, B., Fumagalli, G., Gloor, SM., Kunz, B. & Sonderegger, P. Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction. J Cell Sci. 123, 3944-3955 (2010).

Dityatev, A., Schachner, M. & Sonderegger, P. The dual role of the extracellular matrix in synaptic plasticity and homeostasis. Nat Rev Neurosci. 11, 735-746 (2010).

Steuble M, Gerrits B, Ludwig A, Mateos JM, Diep TM, Tagaya M, Stephan A, Schätzle P, Kunz B, Streit P & Sonderegger P. Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles. Proteomics. 10, 3775-3788 (2010).

Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, Kümpfel T, Moldenhauer A, Rader C, Sonderegger P, Pöllmann W, Tiefenthaller C, Bauer J, Lassmann H, Wekerle H, Karagogeos D, Hohlfeld R, Linington C & Meinl E. Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad Sci U S A. 106, 8302-8327 (2009).

Ludwig, A., Blume, J., Diep, TM., Yuan, J., Mateos, JM., Leuthäuser, K., Steuble, M., Streit, P. & Sonderegger, P. Calsyntenins mediate TGN exit of APP in a Kinesin-1-dependent manner. Traffic  10, 572-589 (2009).

Matsumoto-Miyai K, Sokolowska E, Zurlinden A, Gee CE, Lüscher D, Hettwer S, Wölfel J, Ladner AP, Ster J, Gerber U, Rülicke T, Kunz B & Sonderegger P. Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage. Cell  136, 1161-1171 (2009).

Coutelier, M., Andries, S., Ghariani, S., Dan, B., Duyckaerts, C., van Rijckevorsel, K., Raftopoulos, C., Deconinck, N., Sonderegger, P., Scaravilli, F., Vikkula, M. & Godfraind, C. Neuroserpin mutation causes electrical status epilepticus of slow-wave sleep. Neurology 71, 64-66 (2008). 

Frischknecht, R., Fejtova, A., Viesti, M., Stephan, A. & Sonderegger, P. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J. Neurosci. 28, 1568-1579 (2008).

Lebeurrier, N., Launay, S., Macrez, R., Maubert, E., Legros H., Leclerc, A., Jamin, SP., Picard, JY., Marret, S. Laudenbach, V., Berger, P., Sonderegger, P., Ali, C., di Clemente, N. & Vivien, D. Anti-Mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpin. J Cell Sci. 121, 3357-3365 (2008).

Reif, R., Sales, S., Dreier, B., Lüscher, D., Wölfel, J., Gisler, C., Baici, A., Kunz, B. & Sonderegger, P. Purification and enzymological characterization of murine neurotrypsin. Protein Expr. Purif. 61, 13-21 (2008).

Rindler, MJ., Xu, CF., Gumper, I., Cen, C., Sondergger, P. & Neubert, TA. Calsynthenins are secretory granule proteins in anterior pituitary gland and pancreatic islet alpha cells. J. Histochem. Cytochem. 56, 381-388 (2008).

Stephan, A., Mateos, JM., Kozlov, SV., Cinelli, P., Kistler, AD., Hettwer, S., Rülicke, T. , Streit, P., Kunz, B. & Sonderegger, P. Neurotrypsin cleaves agrin locally at the synpase. FASEB J. 22, 1861-1873 (2008). 

Galliciotti, G., Glatzel, M., Kinter, J., Kozlov, SV., Cinelli, P., Rulicke, T. & Sonderegger, P. Accumulation of mutant neuroserpin precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies. Am J Pathol. 170, 1305-13 (2007). 

Gourfinkel-An, I., Duyckaerts, C., Camuzat, A., Meyrignac, C., Sondergger, P., Baulac, M. & Brice, A. Clinical and neuropathologic study of a French family with a mutation in the neuroserpin gene. Neurology 69, 79-83 (2007).

Mörtl, M., Sonderegger, P., Diederichs, K. & Welte, W. The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction. Protein Sci 16, 2174-2183 (2007).

Reif, R., Sales, S., Hettwer, S., Dreier, B., Gisler, C., Wölfel, J., Lüscher, D., Zurlinden, A., Stephan, A., Ahmed, S., Baici, A., Ledermann, B., Kunz, B. & Sondergger, P. Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J. 21, 3468-3478 (2007).

Sonderegger, P. & Patty, L. Comment on "Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila". Science 16,1698 (2007).

Galliciotti, G. & Sonderegger, P. Neuroserpin. Frontiers in Bioscience 11, 33-45 (2006).

Konecna, A., Frischknecht, R., Kinter, J., Ludwig, A., Steuble, M., Meskenaite, V., Indermuhle, M., Engel, M., Cen, C., Mateos, J. M., Streit, P. & Sonderegger, P. Calsyntenin-1 docks vesicular cargo to Kinesin-1. Mol. Biol. Cell 17, 3651-3663 (2006).

Simonin, Y., Charron, Y., Sonderegger, P., Vassalli, JD. & Kato AC. An inhibitor of serine proteases, neuroserpin, acts as a neuroprotective agent in a mouse model of neurodegenerative disease. J Neurosci. 26, 10614-9 (2006). 

Lebeurrier, N., Liot, G., Lopez-Atalaya, J. P., Orset, C., Fernandez-Monreal, M., Sonderegger, P., Ali, C. & Vivien, D. The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo. Mol. Cell. Neurosci. 30, 552-558 (2005).

Schrimpf, S. P., Meskenaite, V., Brunner, E., Rutishauser, D., Walther, P., Eng, J., Aebersold, R. & Sonderegger, P. Proteomic analysis of synaptosomes using isotope-coded affinity tags and mass spectrometry. Proteomics 5, 2531-2541 (2005).

Navarro-Yubero, C., Cuadrado, A., Sonderegger, P. & Munoz, A. Neuroserpin is post-transcriptionally regulated by thyroid hormone. Mol. Brain Res. 123, 56-65 (2004).

Madani, R., Kozlov, S., Akhmedov, A., Cinelli, P., Kinter, J., Lipp, H. P., Sonderegger, P. & Wolfer, D. P. Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin. Mol. Cell. Neurosci. 23, 473-494 (2003).

Molinari, F., Meskanaite, V., Munnich, A., Sonderegger, P. & Colleaux, L. Extracellular proteases and their inhibitors in genetic diseases of the central nervous system. Human Mol. Genet. 12, R195-R200 (2003).

Wannier-Morino, P., Rager, G., Sonderegger, P. & Grabs, D. Expression of neuroserpin in the visual cortex of the mouse during the developmental critical period. Eur. J. Neurosci. 17, 1853-1860 (2003).

Cuadrado, A., Navarro-Yubero, C., Furneaux, H., Kinter, J., Sonderegger, P. & Munoz, A. HuD binds to three AU-rich sequences in the 3 '-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein. Nucleic Acids Res. 30, 2202-2211 (2002).

Hintsch, G., Zurlinden, A., Meskenaite, V., Steuble, M., Fink-Widmer, K., Kinter, J. & Sonderegger, P. The calsyntenins - A family of postsynaptic membrane proteins with distinct neuronal expression patterns. Mol. Cell. Neurosci. 21, 393-409 (2002).

Kunz, B., Lierheimer, R., Rader, C., Spirig, M., Ziegler, U. & Sonderegger, P. Axonin-1/TAG-1 mediates cell-cell adhesion by a cis-assisted trans-interaction. J. Biol. Chem. 277, 4551-4557 (2002).

Molinari, F., Rio, M., Meskenaite, V., Encha-Razavi, F., Auge, J., Bacq, D., Briault, S., Vekemans, M., Munnich, A., Attie-Bitach, T., Sonderegger, P. & Colleaux, L. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science 298, 1779-1781 (2002).

Alvarez-Dolado, M., Figueroa, A., Kozlov, S., Sonderegger, P., Furley, A. J. & Munoz, A. Thyroid hormone regulates TAG-1 expression in the developing rat brain. Eur. J. Neurosci. 14, 1209-1218 (2001).

Bernard, A., Fitzli, D., Sonderegger, P., Delamarche, E., Michel, B., Bosshard, H. R. & Biebuyck, H. Affinity capture of proteins from solution and their dissociation by contact printing. Nat. Biotechnol. 19, 866-869 (2001). 

Briand, C., Kozlov, S. V., Sonderegger, P. & Grutter, M. G. Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease. Febs Lett. 505, 18-22 (2001).

Cinelli, P., Madani, R., Tsuzuki, N., Vallet, P., Arras, M., Zhao, C. N., Osterwalder, T., Rulicke, T. & Sonderegger, P. Neuroserpin, a neuroprotective factor in focal ischemic stroke. Mol. Cell. Neurosci. 18, 443-457 (2001).

Modestin, J., Sonderegger, P. & Erni, T. Follow-up study of hysterical psychosis, reactive/psychogenic psychosis, and schizophrenia. Comprehensive Psychiatry 42, 51-56 (2001).

Plagge, A., Sendtner-Voelderndorff, L., Sirim, P., Freigang, J., Rader, C., Sonderegger, P. & Brummendorf, T. The contactin-related protein FAR-2 defines Purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum. Mol. Cell. Neurosci. 18, 91-107 (2001).

Silverman, M. A., Kaech, S., Jareb, M., Burack, M. A., Vogt, L., Sonderegger, P. & Banker, G. Sorting and directed transport of membrane proteins during development of hippocampal neurons in culture. Proc. Natl. Acad. Sci. USA 98, 7051-7057 (2001).

Sorribas, H., Braun, D., Leder, L., Sonderegger, P. & Tiefenauer, L. Adhesion proteins for a tight neuron-electrode contact. J. Neurosci. Meth. 104, 133-141 (2001).

Vogt, L., Schrimpf, S. P., Meskenaite, V., Frischknecht, R., Kinter, J., Leone, D. P., Ziegler, U. & Sonderegger, P. Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Mol. Cell. Neurosci. 17, 151-166 (2001).

Wolfer, D. P., Lang, R., Cinelli, P., Madani, R. & Sonderegger, P. Multiple roles of neurotrypsin in tissue morphogenesis and nervous system development suggested by the mRNA expression pattern. Mol. Cell. Neurosci. 18, 407-433 (2001).

Alvarez-Dolado, M., Cuadrado, A., Navarro-Yubero, C., Sonderegger, P., Furley, A. J., Bernal, J. & Munoz, A. Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain. Mol. Cell. Neurosci. 16, 499-514 (2000).

Camuzat, A., Verpillat, P., Dubois, B., Penet, C., Agid, C. P. Y., Brice, A., Clerget-Darpoux, F., Moreaud, O., Puel, M., Kinter, J., Kozlov, S., Berger, P., Sonderegger, P., Raux, G., Campion, D., Hannequin, D., Frebourg, T. Mutations in the neuroserpin gene are rare in familial dementia. Annals of Neurology 47, 688-688 (2000).

Finckh, U., Muller-Thomsen, T., Mann, U., Eggers, C., Marksteiner, J., Meins, W., Binetti, G., Alberici, A., Sonderegger, P., Hock, C., Nitsch, R. M. & Gal, A. High frequency of mutations in four different disease genes in early-onset dementia. Molecular Basis of Dementia 920, 100-106 (2000). 

Fitzli, D., Stoeckli, E. T., Kunz, S., Siribour, K., Rader, C., Kunz, B., Kozlov, S. V., Buchstaller, A., Lane, R. P., Suter, D. M., Dreyer, W. J. & Sonderegger, P. A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axone. J. Cell Biol. 149, 951-968 (2000).

Freigang, J., Proba, K., Leder, L., Diederichs, K., Sonderegger, P. & Welte, W. The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion. Cell 101, 425-433 (2000).

Gennarini, G., Kozlov, S., Sonderegger, P. & Furley, A. Misexpression of the mouse F3 axonal glycoprotein under the transient axonal glycoprotein promoter results in a cerebellar phenotype in early development. Eur. J. Neurosci. 12, 275-275 (2000).

Plagge, A., Sendtner-Voelderndorff, L., Sirim, P., Rader, C., Sonderegger, P. & Brummendorf, T. Zebra stripes in the cerebellum: Identification of a neurite outgrowth related protein expressed in sagittal zones in the cerebellar cortex. Eur. J. Neurosci. 12, 276-276 (2000).

Sampo, B., Banker, G. A. & Sonderegger, P. Sorting signals that target NgCAM to the axonal plasma membrane in cultured hippocampal neurons. Mol. Biol. Cell 11, 321a-322a (2000).

Berger, P., Kozlov, S. V., Cinelli, P., Kruger, S. R., Vogt, L. & Sonderegger, P. Neuronal depolarization enhances the transcription of the neuronal serine protease inhibitor neuroserpin. Mol. Cell. Neurosci. 14, 455-467 (1999).

Davis, R. L., Shrimpton, A. E., Holohan, P. D., Bradshaw, C., Feiglin, D., Collins, G. H., Sonderegger, P., Kinter, J., Becker, L. M., Lacbawan, F., Krasnewich, D., Muenke, M., Lawrence, D. A., Yerby, M. S., Shaw, C. M., Gooptu, B., Elliott, P. R., Finch, J. T., Carrell, R. W. & Lomas, D. A. Familial dementia caused by polymlerization of mutant neurosergin. Nature 401, 376-379 (1999). 

Kozlov, S. V., Riegel, M., Kinter, J., Hintsch, G., Cinelli, P., Schinzel, A. & Sonderegger, P. Assignment of the gene encoding the neuronal multidomain serine protease neurotrypsin (PRSS12) to human chromosome band 4q25 -> q26 by in situ hybridization. Cytogenetics and Cell Genetics 84, 107-108 (1999).

Kunz, S., Fitzli, D., Siribour, K., Leder, L., Freigang, J., Welte, W. & Sonderegger, P. Binding topology and axon growth and guidance function of axonin-1/NgCAM and axonin-1/NrCAM complexes. J. Neurochem. 73, S64-S64 (1999).

Sorribas, H., Padeste, C., Mezzacasa, T., Tiefenauer, L., Leder, L., Fitzli, D. & Sonderegger, P. Neurite outgrowth on microstructured surfaces functionalized by a neural adhesion protein. Journal of Materials Science-Materials in Medicine 10, 787-791 (1999).

Berger, P., Kozlov, S. V., Krueger, S. R. & Sonderegger, P. Structure of the mouse gene for the serine protease inhibitor neuroserpin (PI12). Gene 214, 25-33 (1998).

Kunz, S., Spirig, M., Ginsburg, C., Buchstaller, A., Berger, P., Lanz, R., Rader, C., Vogt, L., Kunz, B. & Sonderegger, P. Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule. J. Cell Biol. 143, 1673-1690 (1998).

Osterwalder, T., Cinelli, P., Baici, A., Pennella, A., Krueger, S. R., Schrimpf, S. P., Meins, M. & Sonderegger, P. The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin. J. Biol. Chem. 273, 2312-2321 (1998).

Proba, K., Gschwend, T. P. & Sonderegger, P. Cloning and sequencing of the cDNA encoding human neurotrypsin. Biochim. Biophys. Acta-Gene Structure and Expression 1396, 143-147 (1998).

Sonderegger, P., Kunz, S., Rader, C., Buchstaller, A., Berger, P., Vogt, L., Kozlov, S. V., Ziegler, U., Kunz, B., Fitzli, D. & Stoeckli, E. T. Discrete clusters of axonin-1 and NgCAM at neuronal contact sites: Facts and speculations on the regulation of axonal fasciculation. Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy 117, 93-104 (1998).

Wolfer, D. P., Giger, R. J., Stagliar, M., Sonderegger, P. & Lipp, H. P. Expression of the axon growth-related neural adhesion molecule TAG-1/axonin-1 in the adult mouse brain. Anatomy and Embryology 197, 177-185 (1998).

Stoeckli, E. T., Sonderegger, P., Pollerberg, G. E. & Landmesser, L. T. Interference with axonin-1 and NrCAM interactions unmasks a floor-plate activity inhibitory for commissural axons. Neuron 18, 209-221 (1997).

Sonderegger, P. Axonin-1 and NgCAM as ''recognition'' components of the pathway sensor apparatus of growth cones: a synopsis. Cell Tissue Res. 290, 429-439 (1997).

Schrimpf, S. P., Bleiker, A. J., Brecevic, L., Kozlov, S. V., Berger, P., Osterwalder, T., Krueger, S. R., Schinzel, A. & Sonderegger, P. Human neuroserpin (PI12): cDNA cloning and chromosomal localization to 3q26. Genomics 40, 55-62 (1997).

Lierheimer, R., Kunz, B., Vogt, L., Savoca, R., Brodbeck, U. & Sonderegger, P. The neuronal cell-adhesion molecule axonin-1 is specifically released by an endogenous glycosylphosphatidylinositol-specific phospholipase. Eur. J. Biochem. 243, 502-510 (1997).

Krueger, S. R., Ghisu, G. P., Cinelli, P., Gschwend, T. P., Osterwalder, T., Wolfer, D. P. & Sonderegger, P. Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J. Neurosci. 17, 8984-8996 (1997).

Gschwend, T. P., Krueger, S. R., Kozlov, S. V., Wolfer, D. P. & Sonderegger, P. Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. Mol. Cell. Neurosci. 9, 207-219 (1997).

Giger, R. J., Ziegler, U., Hermens, W. T. J. M. C., Kunz, B., Kunz, S. & Sonderegger, P. Adenovirus-mediated gene transfer in neurons: Construction and characterization of a vector for heterologous expression of the axonal cell adhesion molecule axonin-1. J. Neurosci. Meth. 71, 99-111 (1997).

Denzinger, T., Przybylski, M., Savoca, R. & Sonderegger, P. Mass spectrometric characterisation of primary structure, sequence heterogeneity, and intramolecular disulfide loops of the cell adhesion protein axonin-1 from chicken. European Mass Spectrometry 3, 379-389 (1997).

Vogt, L., Giger, R. J., Ziegler, U., Kunz, B., Buchstaller, A., Hermens, W. T. J. M. C., Kaplitt, M. G., Rosenfeld, M. R., Pfaff, D. W., Verhaagen, J. & Sonderegger, P. Continuous renewal of the axonal pathway sensor apparatus by insertion of new sensor molecules into the growth cone membrane. Curr. Biol. 6, 1153-1158 (1996).

Stoeckli, E. T., Ziegler, U., Bleiker, A. J., Groscurth, P. & Sonderegger, P. Clustering and functional cooperation of Ng-CAM and axonin-1 in the substratum-contact area of growth cones. Dev. Biol. 177, 15-29 (1996).

Rager, G., Morino, P., Schnitzer, J. & Sonderegger, P. Expression of the axonal cell adhesion molecules axonin-1 and Ng-CAM during the development of the chick retinotectal system. J. Comp. Neurol. 365, 594-609 (1996).

Rader, C., Kunz, B., Lierheimer, R., Giger, R. J., Berger, P., Tittmann, P., Gross, H. & Sonderegger, P. Implications for the domain arrangement of axonin-1 derived from the mapping of its NgCAM binding site. EMBO J. 15, 2056-2068 (1996).

Osterwalder, T., Contartese, J., Stoeckli, E. T., Kuhn, T. B. & Sonderegger, P. Neuroserpin, an axonally secreted serine protease inhibitor. EMBO J. 15, 2944-2953 (1996).

Morino, P., Buchstaller, A., Giger, R., Sonderegger, P. & Rager, G. Differential expression of the mRNAs of the axonal glycoproteins axonin-1 and NgCAM in the developing chick retina. Dev. Brain Res. 91, 252-259 (1996).

Kunz, S., Ziegler, U., Kunz, B. & Sonderegger, P. Intracellular signaling is changed after clustering of the neural cell adhesion molecules axonin-1 and NgCAM during neurite fasciculation. J. Cell Biol. 135, 253-267 (1996).

Buchstaller, A., Kunz, S., Berger, P., Kunz, B., Ziegler, U., Rader, C. & Sonderegger, P. Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion. J. Cell Biol. 135, 1593-1607 (1996).

Ziegler, U., Giger, R. J., Kunz, B., Vogt, L., Kunz, S., Hermens, W. T. J. M. C., Kaplitt, M. G., Rosenfeld, M. R., Pfaff, D. W., Verhaagen, J. & Sonderegger, P. Adenovirus-Mediated Transfection of Neurons with the Cell-Adhesion Molecule Axonin-1. Mol. Biol. Cell 6, 571-571 (1995).

Suter, D. M., Pollerberg, G. E., Buchstaller, A., Giger, R. J., Dreyer, W. J. & Sonderegger, P. Binding between the Neural Cell-Adhesion Molecules Axonin-1 and Nr-Cam/Bravo Is Involved in Neuron-Glia Interaction. J. Cell Biol. 131, 1067-1081 (1995).

Savoca, R., Ziegler, U. & Sonderegger, P. Effects of L-Serine on Neurons in-Vitro. J. Neurosci. Meth. 61, 159-167 (1995).

Kozlov, S. V., Giger, R. J., Hasler, T., Korvatska, E., Schorderet, D. F. & Sonderegger, P. The Human Tax1 Gene Encoding the Axon-Associated Cell-Adhesion Molecule Tag-1/Axonin-1 - Genomic Structure and Basic Promoter. Genomics 30, 141-148 (1995).

Giger, R. J., Vogt, L., Zuellig, R. A., Rader, C., Henehanbeatty, A., Wolfer, D. P. & Sonderegger, P. The Gene of Chicken Axonin-1 - Complete Structure and Analysis of the Promoter. Eur. J. Biochem. 227, 617-628 (1995).

Wolfer, D. P., Henehanbeatty, A., Stoeckli, E. T., Sonderegger, P. & Lipp, H. P. Distribution of Tag-1/Axonin-1 in Fiber Tracts and Migratory Streams of the Developing Mouse Nervous-System. J. Comp. Neurol. 345, 1-32 (1994).

Rader, C., Stoeckli, E. T., Ziegler, U., Osterwalder, T., Kunz, B. & Sonderegger, P. Cell-Cell Adhesion by Homophilic Interaction of the Neuronal Recognition Molecule Axonin-1. Eur. J. Biochem. 215, 133-141 (1993).

Kenwrick, S., Leversha, M., Rooke, L., Hasler, T. & Sonderegger, P. Localization of the Human Tax-1 Gene to 1q32.1 - a Region Implicated in Microcephaly and Vanderwoude Syndrome. Human Molecular Genetics 2, 1461-1462 (1993).

Hasler, T. H., Rader, C., Stoeckli, E. T., Zuellig, R. A. & Sonderegger, P. Cdna Cloning, Structural Features, and Eukaryotic Expression of Human Tag-1/Axonin-1. Eur. J. Biochem. 211, 329-339 (1993).

Amberger, A., Lemkin, P. F., Sonderegger, P. & Bauer, H. C. Ecgf and Heparin Determine Differentiation of Cloned Cerebral Endothelial-Cells in-Vitro. Mol. Chem. Pathol. 20, 33-43 (1993).

Zuellig, R. A., Rader, C., Schroeder, A., Kalousek, M. B., Vonbohlen, F., Osterwalder, T., Inan, C., Stoeckli, E. T., Halbach, F., Affolter, H. U., Fritz, A., Hafen, E. & Sonderegger, P. The Axonally Secreted Cell-Adhesion Molecule, Axonin-1 - Primary Structure, Immunoglobulin-Like and Fibronectin-Type-Iii-Like Domains and Glycosyl-Phosphatidylinositol Anchorage. Eur. J. Biochem. 204, 453-463 (1992).

Sonderegger, P. & Rathjen, F. G. Regulation of Axonal Growth in the Vertebrate Nervous-System by Interactions between Glycoproteins Belonging to 2 Subgroups of the Immunoglobulin Superfamily. J. Cell Biol. 119, 1387-1394 (1992).

Sonderegger, P. Molecular Mechanism of Neurite Outgrowth on Axonin-1(Tag-1). Eur. J. Neurosci. 88-88 (1992).

Stoeckli, E. T., Kuhn, T. B., Duc, C. O., Ruegg, M. A. & Sonderegger, P. The Axonally Secreted Protein Axonin-1 Is a Potent Substratum for Neurite Growth. J. Cell Biol. 112, 449-455 (1991).

Kuhn, T. B., Stoeckli, E. T., Condrau, M. A., Rathjen, F. G. & Sonderegger, P. Molecular Analysis of Neurite Outgrowth on Axonin-1. Biol. Chem. Hoppe-Seyler 372, 886-887 (1991).

Kuhn, T. B., Stoeckli, E. T., Condrau, M. A., Rathjen, F. G. & Sonderegger, P. Neurite Outgrowth on Immobilized Axonin-1 Is Mediated by a Heterophilic Interaction with L1(G4). J. Cell Biol. 115, 1113-1126 (1991).

Stoeckli, E. T., Lemkin, P. F., Kuhn, T. B., Ruegg, M. A., Heller, M. & Sonderegger, P. Identification of Proteins Secreted from Axons of Embryonic Dorsal-Root-Ganglia Neurons. Eur. J. Biochem. 180, 249-258 (1989).

Ruegg, M. A., Stoeckli, E. T., Lanz, R. B., Streit, P. & Sonderegger, P. A Homolog of the Axonally Secreted Protein Axonin-1 Is an Integral Membrane-Protein of Nerve-Fiber Tracts Involved in Neurite Fasciculation. J. Cell Biol. 109, 2363-2378 (1989).

Ruegg, M. A., Stoeckli, E. T., Kuhn, T. B., Heller, M., Zuellig, R. & Sonderegger, P. Purification of Axonin-1, a Protein That Is Secreted from Axons during Neurogenesis. EMBO J. 8, 55-63 (1989).

Haselbacher, G., Groscurth, P., Otten, U., Vedder, H., Lutz, U., Sonderegger, P., Bulatko, A., Greeff, N. & Humbel, R. Long-Term Cultivation of Cryopreserved Human-Fetal Brain-Cells in a Chemically Defined Medium. J. Neurosci. Meth. 30, 121-131 (1989).

Stockli, E. T., Kuhn, T. B., Ruegg, M. A., Heller, M. & Sonderegger, P. Axonally Secreted Proteins .1. Identification. Experientia 43, 658-658 (1987).

Ruegg, M. A., Stockli, E. T., Kuhn, T. B., Heller, M. & Sonderegger, P. Axonally Secreted Proteins .2. Purification of Asp-140 and Determination of Neurons as Target-Cells. Experientia 43, 657-657 (1987).

Heller, M., Ruegg, M. A., Stockli, E. T. & Sonderegger, P. A Monoclonal-Antibody against the Cell-Surface of a Subpopulation of Astrocytes. Experientia 43, 655-655 (1987).

Sonderegger, P., Lemkin, P. F., Lipkin, L. E. & Nelson, P. G. Coordinate Regulation of the Expression of Axonal Proteins by the Axonal Microenvironment. Dev. Biol. 118, 222-232 (1986).

Sonderegger, P., Lemkin, P. F., Lipkin, L. E. & Nelson, P. G. Differential Modulation of the Expression of Axonal Proteins by Non-Neuronal Cells of the Peripheral and Central Nervous-System. EMBO J. 4, 1395-1401 (1985).

Sonderegger, P., Lemkin, P. F., Lipkin, L. E. & Nelson, P. G. Clusters of Axonal Proteins with Similar Environmental Modulation Profiles - Cues for Proteins That Cooperate in Particular Axonal Functions. Experientia 41, 812-812 (1985).

Bauer, H. C., Hasegawa, S., Sonderegger, P., Daniels, M. P. & Pudimat, P. Specificity of Neuronal Factors Which Aggregate Acetylcholine-Receptors on Cultured Myotubes. Exp. Cell Res. 157, 288-292 (1985).

Sonderegger, P., Lemkin, P. F., Lipkin, L. E. & Nelson, P. G. Differential Modulation of the Synthesis of Axonal Proteins of Dorsal-Root Ganglia by Peripheral and Central Neuroglial Cells. Experientia 40, 638-638 (1984).

Sonderegger, P., Fishman, M. C., Bokoum, M., Bauer, H. C., Neale, E. A. & Nelson, P. G. A Few Axonal Proteins Distinguish Ventral Spinal-Cord Neurons from Dorsal-Root Ganglion Neurons. J. Cell Biol.  98, 364-368 (1984).

Lemkin, P. F., Sonderegger, P. & Lipkin, L. E. Identification of Coordinate Pairs of Polypeptides - a Technique for Screening of Putative Precursor Product Pairs in 2d Gels. Clinical Chemistry 30, 1965-1971 (1984).

Daniels, M. P., Vigny, M., Sonderegger, P., Bauer, H. C. & Vogel, Z. Association of Laminin and Other Basement-Membrane Components with Regions of High Acetylcholine-Receptor Density on Cultured Myotubes. Int. J. Dev. Neurosci. 2, 87-99 (1984).

Busis, N. A., Daniels, M. P., Bauer, H. C., Pudimat, P. A., Sonderegger, P., Schaffner, A. E. & Nirenberg, M. 3 Cholinergic Neuro-Blastoma Hybrid Cell-Lines That Form Few Synapses on Myotubes Are Deficient in Acetylcholine-Receptor Aggregation Molecules and Large Dense Core Vesicles. Brain Res. 324, 201-210 (1984).

Vogel, Z., Christian, C. N., Vigny, M., Bauer, H. C., Sonderegger, P. & Daniels, M. P. Laminin Induces Acetylcholine-Receptor Aggregation on Cultured Myotubes and Enhances the Receptor Aggregation Activity of a Neuronal Factor. J. Neurosci. 3, 1058-1068 (1983).

Sonderegger, P., Fishman, M. C., Bokoum, M., Bauer, H. C. & Nelson, P. G. Axonal Proteins of Pre-Synaptic Neurons during Synaptogenesis. Science 221, 1294-1297 (1983).

Sonderegger, P., Fishman, M. C., Bauer, H. C. & Nelson, P. G. Changes in the Pattern of Synthesis of Axonal Proteins Concomitant with Synapse Formation. Experientia 39, 674-674 (1983).

Sonderegger, P., Jaussi, R., Gehring, H., Brunschweiler, K. & Christen, P. Direct Peptide-Mapping of Protein Bands from Polyacrylamide-Gel Electrophoresis by Chemical Cleavage in Gel Pieces and Re-Electrophoresis. Experientia 38, 732-732 (1982).

Sonderegger, P., Jaussi, R., Gehring, H., Brunschweiler, K. & Christen, P. Peptide-Mapping of Protein Bands from Polyacrylamide-Gel Electrophoresis by Chemical Cleavage in Gel Pieces and Re-Electrophoresis. Anal. Biochem. 122, 298-301 (1982).

Sonderegger, P., Jaussi, R., Christen, P. & Gehring, H. Biosynthesis of Aspartate Aminotransferases - Both the Higher Molecular-Weight Precursor of Mitochondrial Aspartate-Aminotransferase and the Cytosolic Isoenzyme Are Synthesized on Free Polysomes. J. Biol. Chem. 257, 3339-3345 (1982).

Jaussi, R., Sonderegger, P., Fluckiger, J. & Christen, P. Biosynthesis and Topogenesis of Aspartate-Aminotransferase Isoenzymes in Chicken-Embryo Fibroblasts - the Precursor of the Mitochondrial Isoenzyme Is Either Imported into Mitochondria or Degraded in the Cytosol. J. Biol. Chem. 257, 3334-3340 (1982).

Jaussi, R., Sonderegger, P. & Christen, P. Rapid Degradation of the Precursor of Mitochondrial Aspartate-Aminotransferase in Uncoupler-Treated Chicken-Embryo Fibroblasts. Experientia 38, 742-742 (1982).

Behra, R., Christen, P., Spycher, M. A. & Sonderegger, P. Sub-Cellular Distribution of Aspartate-Aminotransferase Isoenzymes in Chicken Heart - a Quantitative Study. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology 71, 187-191 (1982).

Wacker, H., Jaussi, R., Sonderegger, P., Dokow, M., Ghersa, P., Hauri, H. P., Christen, P. & Semenza, G. Cell-Free Synthesis of the One-Chain Precursor of a Major Intrinsic Protein Complex of the Small-Intestinal Brush-Border Membrane (Pro-Sucrase-Isomaltase). FEBS Lett. 136, 329-332 (1981).

Jaussi, R., Sonderegger, P. & Christen, P. Demonstration of a Precursor of Mitochondrial Aspartate-Aminotransferase (Maatase) in Cultured Chicken-Embryo Fibroblasts (Cef). Experientia 37, 626-627 (1981).

Behra, R., Christen, P. & Sonderegger, P. Independent Quantitation of the Mitochondrial and the Cytosolic Isoenzyme of Aspartate-Aminotransferase in Chicken Tissues by Radioimmunoassays. J. Biol. Chem. 256, 3381-3384 (1981).

Behra, R., Christen, P. & Sonderegger, P. Aspartate-Aminotransferase Isoenzymes - Intracellular-Localization and Distribution in Different Chicken Tissues Measured by Radioimmunoassay. Experientia 37, 619-619 (1981).

Sonderegger, P., Jaussi, R. & Christen, P. Cell-Free Synthesis of a Putative Precursor of Mitochondrial Aspartate-Aminotransferase with Higher Molecular-Weight. Biochem. Biophys. Res. Commun. 94, 1256-1260 (1980).

Sonderegger, P., Jaussi, R. & Christen, P. Invitro Synthesis of a Putative Precursor of Mitochondrial Aspartate-Aminotransferase. Experientia 35, 985-985 (1979).

Sonderegger, P. & Christen, P. Comparison of Evolution Rates of Cytosolic and Mitochondrial Aspartate-Aminotransferase. Nature 275, 157-159 (1978).

Sonderegger, P., Gehring, H. & Christen, P. Interspecies Comparison of Cytosolic and Mitochondrial Aspartate Aminotransferases - Evidence for a More Conservative Evolution of Mitochondrial Isoenzyme. J. Biol. Chem. 252, 609-612 (1977).

Sonderegger, P. & Christen, P. Mitochondrial Aspartate-Aminotransferase Evolved More Conservatively Than Cytosolic Isoenzyme. Experientia 33, 800-801 (1977).