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Santoro, A., Ewa Wezynfeld, N., Vašák, M., Bal, W. & Faller , M. Cysteine and glutathione trigger the Cu-Zn swap between Cu(ii)-amyloid-β4-16 peptide and Zn7-metallothionein-3. Chem Commun (Camb) 53, 11634-11637 (2017). PMID: 28948272.
Vašák M. & Meloni G. Mammalian methallothionein-3: new functional and structural insights. Int J Mol Sci. 18(6), pii: E1117 (2017). PMID: 28538697.
Vašák, M. & Schnabl, J. Sodium and Potassium Ions in Proteins and Enzyme Catalysis. Met Ions Life Sci 16, 259-90 (2016). PMID: 26860304.
Freisinger, E. & Vasak, M. Cadmium in metallothioneins. Met Ions Life Sci. 11, 339-371 (2013).
Manso,Y., Carrasco, J., Comes, G., Meloni, G., Adlard, PA., Bush, AI, Vasak, M. & Hidalgo, J. Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease. Cell Mol Life Sci. 69, 3683-3700 (2012).
Meloni, G., Crameri, A., Fritz, G., Davies, P., Brown, DR., Kroneck, PM. & Vasak, M. The catalytic redox activity of prion protein-Cu(II) is controlled by metal exchange with the Zn(II)-thiolate clusters of Zn(7) metallothionein-3. Chembiochem. 13, 1261-1265 (2012).
Pedersen, JT., Hureau, C., Hemmingsen, L., Heegard, NH., Ostergaard, J., Vasak, M. & Faller, P. Rapid metal exchange between Zn7-metallothionein-3 and amyloid-beta peptide promotes amyloid related structural changes. Biochemistry 51, 1697-1706 (2012).
Manso, Y., Adlard, PA., Carrasco, J., Vasak, M. & Hidalgo, J. Metallothionein and brain inflammation. J Biol Inorg Chem. 16, 1103-1113 (2011).
Meloni, G. & Vasak, M. Redox activity of a alpha-synuclein-Cu is silenced by Zn(7)-metallothionrin-3. Free Radic Biol Med. 50, 1471-1479 (2011).
Vasak, M. & Meloni, G. Chemistry and biology of mammalian metallothioneins. Biol Inorg Chem 16, 1067-1078 (2011).
Vasak, M. Metallothioneins: chemical and biological challenges. J Biol Inorg Chem. 16, 975-976 (2011).
Durand, J., Meloni, G., Talmard, C., Vasak, M. & Faller, P. Zinc release of Zn(7)-metallothionein-3 induces fibrillar type amyloid-beta aggregates. Metallomics 2, 741-744 (2010).
Manso Y, Serra M, Comes G, Giralt M, Carrasco J, Cols N, Vašák M, González-Duarte P, Hidalgo J. The comparison of mouse full metallothionein-1 versus alpha and beta domains and metallothionein-1- to-3 mutation following traumatic brain injury reveals different biological motifs. J Neurosci Res. 88, 1708-1718 (2010).
Romero-Isart, N., Oliva, B. & Vasak, M. Influence of bonding interactions on the structure and dynamics of metallothioneins. J Mol Model. 16, 387-394 (2010).
Serra-Batiste, M., Cols, N., Alcaraz, LA., Donaire, A., Gonzalez-Duarte, P. & Vasak, M. The metal-binding properties of the blue crab copper specific CuMT-2: a crustacean metallothionein with two cysteine triplets. J. Biol. Inorg. Chem. 15, 759-776 (2010).
Hidalgo, J., Chung, R., Penkowa, M., & Vašák, M., in Metallothioneins and Related Chelators, Structure and Functions of Vertebrate Metallothioneins, Vol. 5 of 'Metal Ions in Life Sciences'; (A. Sigel, H. Sigel, R. K. O. Sigel, Eds.) 279-317 (The Royal Society of Chemistry, Cambridge, UK, 2009)
Karotki, A. & Vasak, M. Reaction of human metallothionein-3 with cisplatin and transplatin. J Biol Inorg Chem 14, 1129-1138 (2009).
Meloni G, Polanski T, Braun O & Vašák M. Effects of Zn(2+), Ca(2+), and Mg (2+) on the structure of Zn(7)methallothionein-3: evidence for an additional zinc binding site. Biochemistry 48, 5700-5777 (2009).
Vašák, M. & Meloni, G., in Metallothioneins and Related Chelators, Metallothionein-3, Zinc, and Copper in the Central Nervous System, Vol. 5 of 'Metal Ions in Life Sciences'; (A. Sigel, H. Sigel, R. K. O. Sigel, Eds.) 319-351 (The Royal Society of Chemistry, Cambridge, UK, 2009)
Karotki, A. & Vasak. M. Interaction of metallothionein-2 with platinum-modified 5'-guanosine monophosphate and DNA. Biochemistry 47, 10961-10969 (2008).
Meloni, G., Sonois, V., Delaine, T., Guilloreau, L., Gillet, A., Teissié, J., Faller, P. & Vasak. M. Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity. Nat Chem Biol. 4, 366-372 (2008).
Vašák, M. & Meloni, G., in Metallothioneins in Biochemistry and Pathology, Metallothionein Structure and Reactivity (P. Zatta Ed.) 1-24 (World Scientific Publishing, Singapore, 2008).
Braun, O., Knipp, M., Chesnov, S., and Vasak, M. Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dmethylargininase-1 and CTP synthetase, Protein Sci. 16, 1522-1534 (2007).
Knipp, M., Karotki, A. V., Chesnov, S., Natile, G., Sadler, P.J., Brabec, V., and Vasak, M. The reaction of Zn7metallothionein with cis- and trans-[Pt(N-donor)2Cl2] anticancer complexes: Trans-PtII complexes retain their N-donor ligands, J. Med. Chem. 50, 4075-4086 (2007).
Koch, M., Bhattacharya, S., Kel, T., Gimona, M., Vasak, M., Chazin, W., Heizmann, C.W., Kroneck, P.M. & Fritz, G. Implications on zinc binding to S100A2. Biochim. Biophys. Acta. 1773, 457-70 (2007).
Meloni G., Faller P. & Vasak M. Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions.J. Biol. Chem. 282, 16068-16078 (2007).
Frey, D., Braun, O., Briand, C., Vasak, M. & Grütter, M. G. Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Structure 14, 901-911 (2006).
Meloni, G., Zovo, K., Kazantseva, J., Palumaa, P. & Vasak, M. Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4. J. Biol. Chem. 281, 14588-14595 (2006).
Penkowa, M., Tio, L., Giralt, M., Quintana, A., Molinero, A., Atrian, S., Vasak, M. & Hidalgo, J. Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury. J. Neurosci. Res. 83, 974-984 (2006).
Knipp, M., Braun, O. & Vasak, M. Searching for DDAH inhibitors: S-nitroso-L-homocysteine is a chemical lead. J. Am. Chem. Soc. 127, 2372-2373 (2005).
Knipp, M., Meloni, G., Roschitzki, B. & Vasak, M. Zn(7)metallothionein-3 and the synaptic vesicle cycle: Interaction of metallothionein-3 with the small GTPase Rab3A. Biochemistry 44, 3159-3165 (2005).
Meloni, G., Knipp, M., Roschitzki, B. & Vasak, M. Metallothionein-3 and the synaptic vesicle cycle: interaction of metallothionein-3 with the small GTPase Rab3A. FEBS Lett. 272, 332-332 (2005).
Meloni, G., Knipp, M. & Vasak, M. Detection of neuronal growth inhibitory factor (metallothionein-3) in polyacrylamide gels and by Western blot analysis. J. Biochem. Biophys. Meth. 64, 76-81 (2005).
Vasak, M. Advances in metallothionein structure and functions. J. Trace Elements Med. Biol. 19, 13-17 (2005).
Knipp, M., Braun, O., Gehrig, P. M., Sack, R. & Vasak, M. Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation. J. Biol. Chem. 278, 3410-3416 (2003).
Roschitzki, B. & Vasak, M. Redox labile site in a Zn-4 cluster of Cu-4,Zn-4-metallothionein-3. Biochemistry 42, 9822-9828 (2003).
Vasak, M. New insights into the role of metal-thiolate clusters in neuronal growth inhibitory factor (metallothionein-3). J. Inorg. Biochem. 96, 25-25 (2003).
Zhang, B., Georgiev, O., Hagmann, M., Gunes, C., Cramer, M., Faller, P., Vasak, M. & Schaffner, W. Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein. Mol. Cell. Biol. 23, 8471-8485 (2003).
Dabrio, M., Rodriguez, A. R., Bordin, G., Bebianno, M. J., De Ley, M., Sestakova, I., Vasak, M. & Nordberg, M. Recent developments in quantification methods for metallothionein. J. Inorg. Biochem. 88, 123-134 (2002).
Fritz, G., Mittl, P. R. E., Vasak, M., Grutter, M. G. & Heizmann, C. W. The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-angstrom resolution. J. Biol. Chem. 277, 33092-33098 (2002).
Romero-Isart, N., Jensen, L. T., Zerbe, O., Winge, D. R. & Vasak, M. Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1. J. Biol. Chem. 277, 37023-37028 (2002).
Romero-Isart, N. & Vasak, M. Advances in the structure and chemistry of metallothioneins. J. Inorg. Biochem. 88, 388-396 (2002).
Roschitzki, B. & Vasak, M. A distinct Cu-4-thiolate cluster of human metallothionein-3 is located in the N-terminal domain. J. Biol. Inorg. Chem. 7, 611-616 (2002).
Hidalgo, J., Aschner, M., Zatta, P. & Vasak, M. Roles of the metallothionein family of proteins in the central nervous system. Brain Res. Bull. 55, 133-145 (2001).
Knipp, M., Charnock, J. M., Garner, C. D. & Vasak, M. Structural and functional characterization of the Zn(II) site in dimethylargininase-1 (DDAH-1) from bovine brain - Zn(II) release activates DDAH-1. J. Biol. Chem. 276, 40449-40456 (2001).
Romero-Isart, N., Jensen, L. T., Zerbe, O., Winge, D. R. & Vasak, M. Engineering of metallothionein-3 neuronal activity into the inactive isoform metallothionein-1: Structural implications. J. Inor. Biochem. 86, 406-406 (2001).
Smyth, E., Syme, C. D., Blanch, E. W., Hecht, L., Vasak, M. & Barron, L. D. Solution structure of native proteins with irregular folds from Raman optical activity. Biopolymers 58, 138-151 (2001).
Troger, W., Ctortecka, B., Faller, P., Vasak, M. (Isolde Collaboration) pH dependent Hg(II) coordination in metallothioneins: a Hg-199m TDPAC study. J. Inorg. Biochem. 86, 460-460 (2001).
Vaher, M., Romero-Isart, N., Vasak, M. & Palumaa, P. Reactivity of Cd-7-metallothionein with Cu(II) ions: evidence for a cooperative formation of Cd-3,Cu(I)(5)-metallothionein. J. Inorg. Biochem. 83, 1-6 (2001).
Vasak, M. Unprecedented dynamics of metal-thiolate clusters in neuronal growth inhibitory factor (metallothionein-3). J. Inorg. Biochem. 86, 110-110 (2001).
Faller, P., Ctortecka, B., Troger, W., Butz, T., Vasak, M. (Isolde Collaboration) Optical and TDPAC spectroscopy of Hg(II)-rubredoxin: model for a mononuclear tetrahedral [Hg(CysS)(4)](2-) center. J. Biol. Inorg. Chem. 393-401 (2000).
Hasler, D. W., Jensen, L. T., Zerbe, O., Winge, D. R. & Vasak, M. Effect of the two conserved prolines of human growth inhibitory factor (metallothionein-3) on its biological activity and structure fluctuation: Comparison with a mutant protein. Biochemistry 39, 14567-14575 (2000).
Jiang, L. J., Vasak, M., Vallee, B. L. & Maret, W. Zinc transfer potentials of the alpha- and beta-clusters of metallothionein are affected by domain interactions in the whole molecule. Proc. Natl. Acad. Sci. USA 97, 2503-2508 (2000).
Knipp, M. & Vasak, M. A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline. Anal. Biochem. 286, 257-264 (2000).
Vasak, M. & Hasler, D. W. Metallothioneins: new functional and structural insights. Curr. Opin. Chem. Biol. 4, 177-183 (2000).
Vasak, M., Hasler, D. W. & Faller, P. Metal-thiolate clusters in neuronal growth inhibitory factor (GIF). J. Inorg. Biochem. 79, 7-10 (2000).
Faller, P., Hasler, D. W., Zerbe, O., Klauser, S., Winge, D. R. & Vasak, M. Evidence for a dynamic structure of human neuronal growth inhibitory factor and for major rearrangements of its metal - Thiolate clusters. Biochemistry 38, 10158-10167 (1999).
Faller, P., Hasler, D. W., Zerbe, O. & Vasak, M. Dynamic structure of metal-thiolate clusters in neuronal growth inhibitory factor (GIF). J J. Inorg. Biochem. 74, 326-326 (1999).
Troger, W., Ctortecka, B., Faller, P., Butz, T., Vasak, M. (Isolde Collaboration) The monomeric thiolate coordination unit of Hg(II) rubredoxin: A Hg-199m-TDPAC study. J. Inorg. Biochem. 74, 318-318 (1999).
Bogumil, R., Faller, P., Binz, P. A., Vasak, M., Charnock, J. M. & Garner, C. D. Structural characterization of Cu(I) and Zn(II) sites in neuronal-growth-inhibitory factor by extended X-ray absorption fine structure (EXAFS). Eur. J. Biochem. 255, 172-177 (1998).
Bogumil, R., Knipp, M., Fundel, S. M. & Vasak, M. Characterization of dimethylargininase from bovine brain: Evidence for a zinc binding site. Biochemistry 37, 4791-4798 (1998).
Bruinink, A., Faller, P., Sidler, C., Bogumil, R. & Vasak, M. Growth inhibitory factor and zinc affect neural cell cultures in a tissue specific manner. Chemico-Biological Interactions 115, 167-174 (1998).
Faller, P. & Vasak, M. Detection of two novel lowest lying singlet-triplet transitions of the C-S-C chromophore in L-methionine. Inorganica Chimica Acta 272, 150-152 (1998).
Hasler, D. W., Faller, P. & Vasak, M. Metal-thiolate clusters in the C-terminal domain of human neuronal growth inhibitory factor (GIF). Biochemistry 37, 14966-14973 (1998).
Roesijadi, G., Bogumil, R., Vasak, M. & Kagi, J. H. R. Modulation of DNA binding of a tramtrack zinc finger peptide by the metallothionein-thionein conjugate pair. J. Biol. Chem. 273, 17425-17432 (1998).
Smith, M. A., Vasak, M., Knipp, M., Castellani, R. J. & Perry, G. Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease. Free Radical Biol. Med. 25, 898-902 (1998).
Vasak, M. Application of Cd-113 NMR to metallothioneins. Biodegradation 9, 501-512 (1998).
Faller, P. & Vasak, M. Distinct metal-thiolate clusters in the N-terminal domain of neuronal growth inhibitory factor. Biochemistry 36, 13341-13348 (1997).
Bogumil, R., Faller, P., Pountney, D. L. & Vasak, M. Evidence for Cu(I) clusters and Zn(II) clusters in neuronal growth-inhibitory factor isolated from bovine brain. Eur. J. Biochem. 238, 698-705 (1996).
Fundel, S. M., Pountney, D. L., Bogumil, R., Gehrig, P. M., Hasler, D. W., Faller, P. & Vasak, M. Isolation and characterization of a novel monomeric zinc- and heme-containing protein from bovine brain. FEBS Lett. 395, 33-38 (1996).
Pountney, D. L., Henehan, C. J. & Vasak, M. Establishing Isostructural Metal Substitution in Metalloproteins Using H-1-Nmr, Circular-Dichroism, and Fourier-Transform Infrared-Spectroscopy. Prot. Sci. 4, 1571-1576 (1995).
Wang, Y. J., Mackay, E. A., Zerbe, O., Hess, D., Hunziker, P. E., Vasak, M. & Kagi, J. H. R. Characterization and Sequential Localization of the Metal-Clusters in Sea-Urchin Metallothionein. Biochemistry 34, 7460-7467 (1995)
Ding, X. Q., Butzlaff, C., Bill, E., Pountney, D. L., Henkel, G., Winkler, H., Vasak, M. & Trautwein, A. X. Mossbauer and Magnetic-Susceptibility Studies on Iron(Ii) Metallothionein from Rabbit Liver - Evidence for the Existence of an Unusual Type of [M(3)(Cyss)(9)](3-) Cluster. Eur. J. Biochem. 220, 827-837 (1994).
Pountney, D. L., Fundel, S. M., Faller, P., Birchler, N. E., Hunziker, P. & Vasak, M. Isolation, Primary Structures and Metal-Binding Properties of Neuronal Growth-Inhibitory Factor (Gif) from Bovine and Equine Brain. FEBS Lett. 345, 193-197 (1994).
Pountney, D. L., Schauwecker, I., Zarn, J. & Vasak, M. Formation of Mammalian Cu-8-Metallothionein in-Vitro - Evidence for the Existence of 2 Cu(I)(4)-Thiolate Clusters. Biochemistry 33, 9699-9705 (1994).
Zerbe, O., Pountney, D. L., Vonphilipsborn, W. & Vasak, M. Vicinal Cd-113,H-1(Beta)-Cysteine Coupling in Cd-Substituted Metalloproteins Follows a Karplus-Type Dependence (Vol 116, Pg 377, 1994). J. Am. Chem. Soc. 116, 7957-7957 (1994).
Zerbe, O., Pountney, D. L., Vonphilipsborn, W. & Vasak, M. Vicinal Cd-113,(H-1)-H-Beta-Cysteine Coupling in Cd-Substituted Metalloproteins Follows a Karplus-Type Dependence. J. Am. Chem. Soc. 116, 377-378 (1994).
Bertini, I., Luchinat, C., Messori, L. & Vasak, M. A 2-Dimensional Nmr-Study of Co(Ii)(7) Rabbit Liver Metallothionein. Eur. J. Biochem. 211, 235-240 (1993).
Henehan, C. J., Pountney, D. L., Zerbe, O. & Vasak, M. Identification of Cysteine Ligands in Metalloproteins Using Optical and Nmr-Spectroscopy - Cadmium-Substituted Rubredoxin as a Model [Cd(Cyss)4]2- Center. Prot. Sci. 2, 1756-1764 (1993).
Palumaa, P., Zerbe, O. & Vasak, M. Formation and Spectroscopic Characterization of a Novel Monomeric Cadmium-Containing and Phosphate-Containing Form of Metallothionein. Biochemistry 32, 2874-2879 (1993).
Braun, W., Vasak, M., Robbins, A. H., Stout, C. D., Wagner, G., Kagi, J. H. R. & Wuthrich, K. Comparison of the Nmr Solution Structure and the X-Ray Crystal-Structure of Rat Metallothionein-2. Proc. Natl. Acad. Sci. USA 89, 10124-10128 (1992).
Comeau, R. D., Mcdonald, K. W., Tolman, G. L., Vasak, M. & Liberatore, F. A. Gram Scale Purification and Preparation of Rabbit Liver Zinc Metallothionein. Prep. Biochem. 22, 151-164 (1992).
Messerle, B. A., Schaffer, A., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Comparison of the Solution Conformations of Human [Zn7]-Metallothionein-2 and [Cd7]-Metallothionein-2 Using Nuclear-Magnetic-Resonance Spectroscopy. J. Mol. Biol. 225, 433-443 (1992).
Palumaa, P., Mackay, E. A. & Vasak, M. Nonoxidative Cadmium-Dependent Dimerization of Cd7-Metallothionein from Rabbit Liver. Biochemistry 31, 2181-2186 (1992).
Palumaa, P. & Vasak, M. Binding of Inorganic-Phosphate to the Cadmium-Induced Dimeric Form of Metallothionein from Rabbit Liver. Eur. J. Biochem. 205, 1131-1135 (1992).
Pountney, D. L. & Vasak, M. Spectroscopic Studies on Metal Distribution in Co(Ii)/Zn(Ii) Mixed-Metal Clusters in Rabbit Liver Metallothionein-2. Eur. J. Biochem. 209, 335-341 (1992).
Rakshit, D. & Vasak, M. Studies on the Assembly and Stability of the Metal-Thiolate Clusters of Metallothionein in Dimethyl-Sulfoxide. J. Biol. Chem. 267, 235-238 (1992).
Good, M., Hollenstein, R. & Vasak, M. Metal Selectivity of Clusters in Rabbit Liver Metallothionein. Eur. J. Biochem. 197, 655-659 (1991).
Vasak, M. Large-Scale Preparation of Metallothionein - Biological Sources. Meth. Enzymol. 205, 39-41 (1991).
Vasak, M. Standard Isolation Procedure for Metallothionein. Meth. Enzymol. 205, 41-44 (1991).
Vasak, M. Criteria of Purity for Metallothioneins. Meth. Enzymol. 205, 44-47 (1991).
Vasak, M. Metal Removal and Substitution in Vertebrate and Invertebrate Metallothioneins. Meth. Enzymol. 205, 452-458 (1991).
Vasak, M. Paramagnetic-Resonance of Metallothionein. Meth. Enzymol. 205, 520-528 (1991).
Messerle, B. A., Bos, M., Schaffer, A., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Amide Proton-Exchange in Human Metallothionein-2 Measured by Nuclear-Magnetic-Resonance Spectroscopy. J. Mol. Biol. 214, 781-786 (1990).
Messerle, B. A., Schaffer, A., Vasak, M., Kagi, J. H. R. & Wuthrich, K. 3-Dimensional Structure of Human [(Cd7)-Cd-113]Metallothionein-2 in Solution Determined by Nuclear-Magnetic-Resonance Spectroscopy. J. Mol. Biol. 214, 765-779 (1990).
Bertini, I., Luchinat, C., Messori, L. & Vasak, M. Proton Nmr-Studies of the Cobalt(Ii)-Metallothionein System. J. Am. Chem. Soc. 111, 7296-7300 (1989).
Bertini, I., Luchinat, C., Messori, L. & Vasak, M. Proton Nmr-Spectra of the Co4s11 Cluster in Metallothioneins - a Theoretical-Model. J. Am. Chem. Soc. 111, 7300-7303 (1989).
Carpene, E. & Vasak, M. Hepatic Metallothioneins from Goldfish (Carassius-Auratus L). Comp. Biochem. Physiol. 92, 463-468 (1989).
Charnock, J. M., Garner, C. D., Abrahams, I. L., Arber, J. M., Hasnain, S. S., Henehan, C. & Vasak, M. Exafs Studies of Metallothionein. Physica 158, 93-94 (1989).
Arseniev, A., Schultze, P., Worgotter, E., Braun, W., Wagner, G., Vasak, M., Kagi, J. H. R. & Wuthrich, K. 3-Dimensional Structure of Rabbit Liver [Cd7]Metallothionein-2a in Aqueous-Solution Determined by Nuclear Magnetic-Resonance. J. Mol. Biol. 201, 637-657 (1988).
Ding, X. Q., Bill, E., Good, M., Trautwein, A. X. & Vasak, M. Mossbauer Studies on the Metal-Thiolate Cluster Formation in Fe(Ii)-Metallothionein. Eur. J. Biochem. 171, 711-714 (1988).
Good, M., Hollenstein, R., Sadler, P. J. & Vasak, M. Cd-113 Nmr-Studies on Metal Thiolate Cluster Formation in Rabbit Cd(Ii)-Metallothionein - Evidence for a Ph-Dependence. Biochemistry 27, 7163-7166 (1988).
Overnell, J., Good, M. & Vasak, M. Spectroscopic Studies on Cadmium(Ii)-Substituted and Cobalt(Ii)-Substituted Metallothionein from the Crab Cancer-Pagurus - Evidence for One Additional Low-Affinity Metal-Binding Site. Eur. J. Biochem. 172, 171-177 (1988).
Schultze, P., Worgotter, E., Braun, W., Wagner, G., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Conformation of [Cd7]-Metallothionein-2 from Rat-Liver in Aqueous-Solution Determined by Nuclear Magnetic-Resonance Spectroscopy. J. Mol. Biol. 203, 251-268 (1988).
Vazquez, F. & Vasak, M. Comparative Cd-113-Nmr Studies on Rabbit (Cd-7)-Cd-113-Depleted (Zn1,Cd6)-Depleted and Partially Metal-Depleted (Cd-6)-Cd-113-Metallothionein-2a. Biochem. J. 253, 611-614 (1988).
Wagner, G., Vasak, M., Worgotter, E., Braun, W., Schultze, P., Arseniev, A. & Wuthrich, K. Solution Structure of Metallothionein from Different Sources as Determined by 2d Nmr. FASEB J. 2, A1738-A1738 (1988).
Worgotter, E., Wagner, G., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Heteronuclear Filters for Two-Dimensional H-1-Nmr - Identification of the Metal-Bound Amino-Acids in Metallothionein and Observation of Small Heteronuclear Long-Range Couplings. J. Am. Chem. Soc. 110, 2388-2393 (1988).
Good, M., Vasak, M. & Kagi, J. H. R. Effects of Cluster Formation on Co(Ii)-Thiolate and Fe(Ii)-Thiolate Excitations in Metallothionein. Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands Chemical Society 106, 186-186 (1987).
Krebs, J., Vasak, M., Scarpa, A. & Carafoli, E. Conformational Differences between the E1 and E2 States of the Calcium Adenosine-Triphosphatase of the Erythrocyte Plasma-Membrane as Revealed by Circular-Dichroism and Fluorescence Spectroscopy. Biochemistry 26, 3921-3926 (1987).
Schaffer, A., Vasak, M. & Kagi, J. H. R. Spectroscopic Investigation of Thiolate Transitions in Metallothionein and in a Model Peptide. Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands Chemical Society 106, 186-187 (1987).
Vasak, M. & Good, M. Spectroscopic Studies on Metal-Thiolate Cluster Formation with Transition and Posttransition Metal-Ions in Metallothionein. Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands Chemical Society 106, 184-184 (1987).
Vasak, M., Worgotter, E., Wagner, G., Kagi, J. H. R. & Wuthrich, K. Metal Coordination in Rat-Liver Metallothionein-2 Prepared with or without Reconstitution of the Metal-Clusters, and Comparison with Rabbit Liver Metallothionein-2. J. Mol. Biol. 196, 711-719 (1987).
Willner, H., Vasak, M. & Kagi, J. H. R. Cadmium-Thiolate Clusters in Metallothionein - Spectrophotometric and Spectropolarimetric Features. Biochemistry 26, 6287-6292 (1987).
Worgotter, E., Wagner, G., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Sequence-Specific H-1-Nmr Assignments in Rat-Liver Metallothionein-2. Eur. J. Biochem. 167, 457-466 (1987).
Wuthrich, K., Schultze, P., Braun, W., Worgotter, E., Wagner, G., Arseniev, A., Vasak, M. & Kagi, J. H. R. Determination of the Metal Coordination in the 3-Dimensional Structure of Metallothionein by Nuclear-Magnetic-Resonance in Aqueous-Solution. Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands Chemical Society 106, 183-183 (1987).
Abrahams, I. L., Bremner, I., Diakun, G. P., Garner, C. D., Hasnain, S. S., Ross, I. & Vasak, M. Structural Study of the Copper and Zinc Sites in Metallothioneins by Using Extended X-Ray-Absorption Fine-Structure. Biochem. J. 236, 585-589 (1986).
Bernhard, W. R., Vasak, M. & Kagi, J. H. R. Cadmium Binding and Metal Cluster Formation in Metallothionein - a Differential Modification Study. Biochemistry 25, 1975-1980 (1986).
Braun, W., Wagner, G., Worgotter, E., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Polypeptide Fold in the 2 Metal-Clusters of Metallothionein-2 by Nuclear-Magnetic-Resonance in Solution. J. Mol. Biol. 187, 125-129 (1986).
Good, M. & Vasak, M. Iron(Ii)-Substituted Metallothionein - Evidence for the Existence of Iron Thiolate Clusters. Biochemistry 25, 8353-8356 (1986).
Good, M. & Vasak, M. Spectroscopic Properties of the Cobalt(Ii)-Substituted Alpha-Fragment of Rabbit Liver Metallothionein. Biochemistry 25, 3328-3334 (1986).
Pande, J., Pande, C., Gilg, D., Vasak, M., Callender, R. & Kagi, J. H. R. Raman, Infrared, and Circular-Dichroism Spectroscopic Studies on Metallothionein - a Predominantly Turn-Containing Protein. Biochemistry 25, 5526-5532 (1986).
Pande, J., Pande, C., Vasak, M., Callender, R. H. & Kagi, J. H. R. Raman Studies on Metallothionein - a Unique, Predominantly Turn Containing Protein. Biophys. J. 49, A117-A117 (1986).
Vasak, M. Dynamic Metal-Thiolate Cluster Structure of Metallothioneins. Environmental Health Perspectives 65, 193-197 (1986).
Vasak, M. & Armitage, I. Nomenclature and Possible Evolutionary Pathways of Metallothionein and Related Proteins - Discussion Summary. Environmental Health Perspectives 65, 215-216 (1986).
Wagner, G., Neuhaus, D., Worgotter, E., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Sequence-Specific H-1-Nmr Assignments in Rabbit-Liver Metallothionein-2. Eur. J. Biochem. 157, 275-289 (1986).
Wagner, G., Neuhaus, D., Worgotter, E., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Nuclear-Magnetic-Resonance Identification of Half-Turn and 310-Helix Secondary Structure in Rabbit Liver Metallothionein-2. J. Mol. Biol. 187, 131-135 (1986).
Weeks, G. H., Adcock, W., Klingensmith, K. A., Waluk, J. W., West, R., Vasak, M., Downing, J. & Michl, J. A Probe for Substituent Hyperconjugative Power - Mcd (Magnetic Circular-Dichroism) of the Benzene Lb Band. Pure Appl. Chem. 58, 39-53 (1986).
Frey, M. H., Wagner, G., Vasak, M., Sorensen, O. W., Neuhaus, D., Worgotter, E., Kagi, J. H. R., Ernst, R. R. & Wuthrich, K. Polypeptide Metal Cluster Connectivities in Metallothionein-2 by Novel H-1-Cd-113 Heteronuclear Two-Dimensional Nmr Experiments. J. Am. Chem. Soc. 107, 6847-6851 (1985).
Neuhaus, D., Wagner, G., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Systematic Application of High-Resolution, Phase-Sensitive Two-Dimensional H-1-Nmr Techniques for the Identification of the Amino-Acid-Proton Spin Systems in Proteins - Rabbit Metallothionein-2. Eur. J. Biochem. 151, 257-273 (1985).
Pande, J., Vasak, M., Gilg, D. & Kagi, J. H. R. Interaction of Lysine Residues with the Metal-Thiolate Clusters in Metallothionein. Biophys. J. 47, A80-A80 (1985).
Pande, J., Vasak, M. & Kagi, J. H. R. Interaction of Lysine Residues with the Metal Thiolate Clusters in Metallothionein. Biochemistry 24, 6717-6722 (1985).
Thornalley, P. J. & Vasak, M. Possible Role for Metallothionein in Protection against Radiation-Induced Oxidative Stress - Kinetics and Mechanism of Its Reaction with Superoxide and Hydroxyl Radicals. Biochim. Biophys. Acta 827, 36-44 (1985).
Vasak, M., Hawkes, G. E., Nicholson, J. K. & Sadler, P. J. Cd-113 Nmr-Studies of Reconstituted 7-Cadmium Metallothionein - Evidence for Structural Flexibility. Biochemistry 24, 740-747 (1985).
Vasak, M., Mcclelland, C. E., Hill, H. A. O. & Kagi, J. H. R. Role of Lysine Side-Chains in Metallothionein. Experientia 41, 30-34 (1985).
Beltramini, M., Lerch, K. & Vasak, M. Metal Substitution of Neurospora Copper Metallothionein. Biochemistry 23, 3422-3427 (1984).
Bernhard, W. R., Vasak, M. & Kagi, J. H. R. Differential Modification of Cd-Metallothionein by Iodoacetamide. Experientia 40, 603-603 (1984).
Kagi, J. H. R., Vasak, M., Lerch, K., Gilg, D. E. O., Hunziker, P., Bernhard, W. R. & Good, M. Structure of Mammalian Metallothionein. Environmental Health Perspectives 54, 93-103 (1984).
Neuhaus, D., Wagner, G., Vasak, M., Kagi, J. H. R. & Wuthrich, K. Cd-113-H-1 Spin-Spin Couplings in Homonuclear H-1 Correlated Spectroscopy of Metallothionein - Identification of the Cysteine H-1 Spin Systems. Eur. J. Biochem. 143, 659-667 (1984).
Vasak, M. Metallothionein - a Novel Class of Diamagnetic Metal Thiolate Cluster Proteins. Journal of Molecular Catalysis 23, 293-302 (1984).
Vasak, M., Berger, C. & Kagi, J. H. R. Dynamic Structure of Metallothionein. FEBS Lett. 168, 174-178 (1984).
Wagner, G., Neuhaus, D., Wuthrich, K., Vasak, M. & Kagi, J. 2d Nmr-Studies of Metallothionein. Experientia 40, 615-615 (1984).
Bernhard, W., Good, M., Vasak, M. & Kagi, J. H. R. Spectroscopic Studies and Characterization of Metallothioneins Containing Mercury, Lead and Bismuth. Inorg. Chim. Acta 79, 154-155 (1983).
Bernhard, W., Vasak, M. & Kagi, J. H. R. Evidence for 2-Different Forms of Hg(Ii)-Metallothionein. Experientia 39, 644-644 (1983).
Ross, I., Binstead, N., Blackburn, N. J., Bremner, I., Diakun, G. P., Hasnain, S. S., Knowles, P. F., Vasak, M. & Garner, C. D. Exafs Studies of Copper and Zinc in Metallothionein and Bovine Superoxide-Dismutase. Inorg. CHim. Acta 79, 89-90 (1983).
Vasak, M. Metallothionein - a Diamagnetic Metal Thiolate Cluster Protein. Inorg. Chim. Acta 79, 15-16 (1983).
Vasak, M. & Kagi, J. H. R. Spectroscopic Properties of Metallothionein. Metal Ions in Biological Systems 15, 213-273 (1983).
Willner, H., Vasak, M. & Kagi, J. H. R. Spectroscopic Evidence for Metal Thiolate Clusters in Complexes of Cd(Ii) with Dithiol Hexapeptides and in Cd-Metallothionein. Inorg. Chim. Acta 79, 106-107 (1983).
Kagi, J. H. R. & Vasak, M. Structure of Mammalian Metallothionein. Federation Proceedings 41, 624-624 (1982).
Vasak, M. & Bauer, R. Evidence for 2 Types of Binding-Sites in Cadmium Metallothionein Determined by Perturbed Angular-Correlation of Gamma-Rays. J. Am. Chem. Soc. 104, 3236-3238 (1982).
Vasak, M., Downing, J. W., Townsend, L. B. & Michl, J. Magnetic Circular-Dichroism of Cyclic Pi-Electron Systems .25. Oxo Derivatives of Indazole, Benzimidazole and Purine. Tetrahedron 38, 1571-1578 (1982).
Vasak, M. & Kagi, J. H. R. Metal-Thiolate Clusters in Metallothionein. Experientia 38, 734-734 (1982).
Messmer, C., Vasak, M. & Kagi, J. H. R. Creatine-Kinase (Ck) - Localization of a Tryptophan Residue at Adenine Binding-Site by Fluorescence Quenching Titration. Experientia 37, 629-629 (1981).
Vasak, M. & Kagi, J. H. R. Metal Thiolate Clusters in Cobalt(Ii)-Metallothionein. Proc. Natl. Acad. Sci. USA 78, 6709-6713 (1981).
Vasak, M., Kagi, J. H. R. & Hill, H. A. O. Zinc(Ii), Cadmium(Ii), and Mercury(Ii) Thiolate Transitions in Metallothionein. Biochemistry 20, 2852-2856 (1981).
Vasak, M., Kagi, J. H. R., Holmquist, B. & Vallee, B. L. Spectral Studies of Cobalt(Ii)-Metallothionein and Nickel(Ii)-Metallothionein. Biochemistry 20, 6659-6664 (1981).
Vasak, M. Spectroscopic Studies on Cobalt(Ii) Metallothionein - Evidence for Pseudotetrahedral Metal Coordination. J. Am. Chem. Soc. 102, 3953-3955 (1980).
Vasak, M., Galdes, A., Hill, H. A. O., Kagi, J. H. R., Bremner, I. & Young, B. W. Investigation of the Structure of Metallothioneins by Proton Nuclear Magnetic-Resonance Spectroscopy. Biochemistry 19, 416-425 (1980).
Vasak, M. & Kagi, J. H. R. Equine Metallothionein (Mt) - Evidence for Tetrahedral Metal Coordination to Sulfur Ligands. Federation Proceedings 39, 2153-2153 (1980).
Nagayama, K., Vasak, M., Wuthrich, K., Mertens, M. L. & Kagi, J. H. R. Creatine-Kinase (Cpk) - Nmr and Fluorescence Evidence for Adp Interaction with Aromatic Residue. Experientia 35, 940-940 (1979).
Vasak, M. & Galdes, A. Proton Nuclear Magnetic-Resonance (Nmr) Studies of Metallothioneins. Experientia 35, 945-945 (1979).
Vasak, M., Nagayama, K., Wuthrich, K., Mertens, M. L. & Kagi, J. H. R. Creatine-Kinase - Nuclear Magnetic-Resonance and Fluorescence Evidence for Interaction of Adenosine 5'-Diphosphate with Aromatic Residue(S). Biochemistry 18, 5050-5055 (1979).
Galdes, A., Vasak, M., Hill, H. A. O. & Kagi, J. H. R. H-1 Nmr-Spectra of Metallothioneins. FEBS Lett. 17-21 (1978).
Vasak, M., Whipple, M. R., Berg, A. & Michl, J. Magnetic Circular-Dichroism of Cyclic Pi-Electron Systems .13. Derivatives of Pyrene. J. Am. Chem. Soc. 100, 6872-6877 (1978).
Vasak, M., Whipple, M. R. & Michl, J. Magnetic Circular-Dichroism of Cyclic Pi-Electron Systems .7. Aza Analogs of Naphthalene. J J. Am. Chem. Soc. 100, 6838-6843 (1978).
Vasak, M., Whipple, M. R. & Michl, J. Magnetic Circular-Dichroism of Cyclic Pi-Electron Systems .12. Aza Analogs of Phenanthrene. J. Am. Chem. Soc. 100, 6867-6871 (1978).
Whipple, M. R., Vasak, M. & Michl, J. Magnetic Circular-Dichroism of Cyclic Pi-Electron Systems .8. Derivatives of Naphthalene. J J. Am. Chem. Soc. 100, 6844-6852 (1978).
Vasak, M. & Kagi, J. H. R. Yeast Alcohol-Dehydrogenase (Yadh) - Spectropolarimetric Evidence for Coenzyme Unfolding on Binding to Active-Site. Federation Proceedings 35, 1541-1541 (1976).
Vasak, M. & Kagi, J. H. R. Circular-Dichroism (Cd) of Enzyme-Coenzyme Complexes of Yeast Alcohol-Dehydrogenase (Yadh) Below 300 Nm. Experientia 31, 725-725 (1975).
Pick, J., Pungor, E., Vasak, M. & Simon, W. Potassium-Selective Silicone-Rubber Membrane Electrode Based on a Neutral Carrier. Anal. Chim. Acta 64, 477-480 (1973).
Pretsch, E., Simon, W. & Vasak, M. 7c-13 Nuclear Magnetic-Resonance Spectroscopic Study on Interaction of Macrotetrolide Antibiotics with Na+, K+, Rb+, Cs+, NH4+ and Ba++. Helvetica Chim. Acta 55, 1098-& (1972).
Sulcek, Z., Vasak, M. & Dolezal, J. Sorption of Complex Cations of Palladium on Silica Gel - Ammine Complexes and Ethylenediamine Complexes. Microchem. J. 16, 210-& (1971).
Simon, W., Wuhrmann, H. R., Vasak, M., Pioda, L. A. R., Dohner, R. & Stefanac, Z. Ion-Selective Sensors. Angewandte Chemie-International Edition 9, 445-& (1970).
