Publications of the Jinek Group

ZORA Publication List

Publications

• 2026

  • Pelea, O., Tálas, A., Fernández Carrera, J., Mathis, N., van de Venn, L., Yeh, C. D., Kulcsár, P. I., Marquart, K. F., Weber, Y., Gerecke, S. E., Harvey-Seutcheu, I. F., Mailänder, D., Pfleiderer, M. M., Chanez, C., Corn, J. E., Schwank, G., & Jinek, M. (2026). Programmable genome editing in human cells using RNA-guided bridge recombinases Science, 391, eadz1884. https://doi.org/10.1126/science.adz1884

• 2025

  • Loeff, L., Kroupova, A., Asanović, I., Boneberg, F. M., Pfleiderer, M. M., Riermeier, L., Leitner, A., Ferdigg, A., Ackle, F., Martinez, J., & Jinek, M. (2025). Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation Nature Structural & Molecular Biology, 32, 1205–1212. https://doi.org/10.1038/s41594-025-01516-6
  • Bobadilla Ugarte, P., Halter, S., Mutte, S. K., Heijstek, C., Niault, T., Terenin, I., Barendse, P., Koopal, B., Roosjen, M., Boeren, S., Hauryliuk, V., Jinek, M., Westphal, A. H., & Swarts, D. C. (2025). Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA Molecular Cell, 85, 1920-1937.e10. https://doi.org/10.1016/j.molcel.2025.03.025
  • Finocchio, G., Querques, I., Chanez, C., Speichert, K. J., & Jinek, M. (2025). Structural basis of TnsC oligomerization and transposase recruitment in type I-B CRISPR-associated transposons Nucleic Acids Research, 53, gkaf149. https://doi.org/10.1093/nar/gkaf149
  • Muhar, M. F., Farnung, J., Cernakova, M., Hofmann, R., Henneberg, L. T., Pfleiderer, M. M., Denoth-Lippuner, A., Kalčic, F., Nievergelt, A. S., Peters Al-Bayati, M., Sidiropoulos, N. D., Beier, V., Mann, M., Jessberger, S., Jinek, M., Schulman, B. A., Bode, J. W., & Corn, J. E. (2025). C-terminal amides mark proteins for degradation via SCF-FBXO31 Nature, 638, 519–527. https://doi.org/10.1038/s41586-024-08475-w
  • Loeff, L., Walter, A., Rosalen, G. T., & Jinek, M. (2025). DNA end sensing and cleavage by the Shedu anti-phage defense system Cell, 188, 721-733.e17. https://doi.org/10.1016/j.cell.2024.11.030
  • Jungfer, K., Moravčík, Š., Garcia-Doval, C., Knörlein, A., Hall, J., & Jinek, M. (2025). Mechanistic determinants and dynamics of cA6 synthesis in type III CRISPR-Cas effector complexes Nucleic Acids Research, 53, gkae1277. https://doi.org/10.1093/nar/gkae1277

• 2024

  • Raimondi, F., Siow, K. M., Wrona, D., Fuster-García, C., Pastukhov, O., Schmitz, M., Bargsten, K., Kissling, L., Swarts, D. C., Andrieux, G., Cathomen, T., Modlich, U., Jinek, M., Siler, U., & Reichenbach, J. (2024). Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements Communications Biology, 7, 1291. https://doi.org/10.1038/s42003-024-06959-z
  • Siow, K. M., Güngör, M., Wrona, D., Raimondi, F., Pastukhov, O., Tsapogas, P., Menzi, T., Schmitz, M., Kulcsár, P. I., Schwank, G., Schulz, A., Jinek, M., Modlich, U., Siler, U., & Reichenbach, J. (2024). Targeted knock-in of NCF1 cDNA into the NCF2 locus leads to myeloid phenotypic correction of p47 $^{phox}$ -deficient chronic granulomatous disease Molecular Therapy : Nucleic Acids, 35, 102229. https://doi.org/10.1016/j.omtn.2024.102229
  • Weibel, N., Curcio, M., Schreiber, A., Arriaga, G., Mausy, M., Mehdy, J., Brüllmann, L., Meyer, A., Roth, L., Flury, T., Pecina, V., Starlinger, K., Dernič, J., Jungfer, K., Ackle, F., Earp, J., Hausmann, M., Jinek, M., Rogler, G., & Antunes Westmann, C. (2024). Engineering a Novel Probiotic Toolkit in Escherichia coli Nissle 1917 for Sensing and Mitigating Gut Inflammatory Diseases ACS Synthetic Biology, 13, 2376–2390. https://doi.org/10.1021/acssynbio.4c00036
  • Loeff, L., Adams, D. W., Chanez, C., Stutzmann, S., Righi, L., Blokesch, M., & Jinek, M. (2024). Molecular mechanism of plasmid elimination by the DdmDE defense system Science, 385, 188–194. https://doi.org/10.1126/science.adq0534
  • Reginato, G., Dello Stritto, M. R., Wang, Y., Hao, J., Pavani, R., Schmitz, M., Halder, S., Morin, V., Cannavo, E., Ceppi, I., Braunshier, S., Acharya, A., Ropars, V., Charbonnier, J.-B., Jinek, M., Nussenzweig, A., Ha, T., & Cejka, P. (2024). HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing Nature Communications, 15, 5789. https://doi.org/10.1038/s41467-024-50080-y
  • Bastiaanssen, C., Bobadilla Ugarte, P., Kim, K., Finocchio, G., Feng, Y., Anzelon, T. A., Köstlbacher, S., Tamarit, D., Ettema, T. J. G., Jinek, M., MacRae, I. J., Joo, C., Swarts, D. C., & Wu, F. (2024). RNA-guided RNA silencing by an Asgard archaeal Argonaute Nature Communications, 15, 5499. https://doi.org/10.1038/s41467-024-49452-1
  • Weber, Y., Böck, D., Ivașcu, A., Mathis, N., Rothgangl, T., Ioannidi, E. I., Blaudt, A. C., Tidecks, L., Vadovics, M., Muramatsu, H., Reichmuth, A., Marquart, K. F., Kissling, L., Pardi, N., Jinek, M., & Schwank, G. (2024). Enhancing prime editor activity by directed protein evolution in yeast Nature Communications, 15, 2092. https://doi.org/10.1038/s41467-024-46107-z
  • Schmidheini, L., Mathis, N., Marquart, K. F., Rothgangl, T., Kissling, L., Böck, D., Chanez, C., Wang, J. P., Jinek, M., & Schwank, G. (2024). Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility Nature Chemical Biology, 20, 333–343. https://doi.org/10.1038/s41589-023-01427-x
  • Pacesa, M., Pelea, O., & Jinek, M. (2024). Past, present, and future of CRISPR genome editing technologies Cell, 187, 1076–1100. https://doi.org/10.1016/j.cell.2024.01.042
  • Finocchio, G., Koopal, B., Potocnik, A., Heijstek, C., Westphal, A. H., Jinek, M., & Swarts, D. C. (2024). Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA Nucleic Acids Research, 52, 2012–2029. https://doi.org/10.1093/nar/gkad1248
  • Saha, A., Ahsan, M., Arantes, P. R., Schmitz, M., Chanez, C., Jinek, M., & Palermo, G. (2024). An alpha-helical lid guides the target DNA toward catalysis in CRISPR-Cas12a Nature Communications, 15, 1473. https://doi.org/10.1038/s41467-024-45762-6
  • Jungfer, K., Sigg, A., & Jinek, M. (2024). Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2 Nucleic Acids Research, 52, 462–473. https://doi.org/10.1093/nar/gkad1102

• 2023

  • Pacesa, M., Loeff, L., Querques, I., Muckenfuss, L. M., Sawicka, M., & Jinek, M. (2023). Publisher Correction: R-loop formation and conformational activation mechanisms of Cas9 Nature, 623, E10. https://doi.org/10.1038/s41586-023-06779-x

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