Publications of the Plückthun Group

ZORA Publication List

Publications

• 2026

  • Ratnayake, D., Galloux, M., Boersma, S., Noerenberg, M., Sizun, C., Sacristan, C., Sourimant, J., Lakerveld, A. J., Gelderloos, A. T., Apperloo, L., Demyanenko, Y., Baars, M. J. D., Banerjee, R., Dreier, B., Furler, S., Mazur, N. I., Bont, L. J., Mohammed, S., Plückthun, A., … Tanenbaum, M. E. (2026). Pre-assembly of biomolecular condensate seeds drives RSV replication Nature, 652, 189–200. https://doi.org/10.1038/s41586-025-10071-5
  • Vukovic, D., Winkelvoß, D., Udovcic, A., Riermeier, L., Jaime-Figueroa, S., Crews, C. M., & Plückthun, A. (2026). Quantitative Degradation Rate Assessment of bioPROTACs Based on Peptide Degrons, E3 Domains, Adapters and Conjugated Small Molecules ACS Chemical Biology, 21(1), 62–73. https://doi.org/10.1021/acschembio.5c00569

• 2025

  • Kolibius, J., Weiss, F., Freitag, P., & Plückthun, A. (2025). Genome-replicating HC-AdV: A novel high-capacity adenoviral vector class featuring enhanced payload expression Molecular Therapy - Methods & Clinical Development, 33, 101582. https://doi.org/10.1016/j.omtm.2025.101582
  • Umbaugh, C. S., Groth, M., Erkut, C., Lee, K.-S., Marinho, J., Linder, S., Iser, F., Kapp, J. N., Schroeter, P., Dolaner, S., Kayserili, A., Helm, D., Schneider, M., Hartmann, J., Walch, P., Barth, T. F. E., Mellert, K., Dreier, B., Schaefer, J. V., … Scholl, C. (2025). Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma Science Advances, 11, eadu2796. https://doi.org/10.1126/sciadv.adu2796
  • Nakadate, M., Kojima, R., Seike, N., Tachibana, R., Fujita, K., Tsuchiya, R., Kamiya, M., Plückthun, A., & Urano, Y. (2025). Design of Antigen-Targeting Fluorogenic Probes Utilizing Intramolecular Addition Reaction of Protein-Dye Hybrids Journal of the American Chemical Society, 147, 30684–30693. https://doi.org/10.1021/jacs.5c04193
  • Vacca, S., Gragera, M., Buschiazzo, A., Herreros, D., Krieger, J. M., Bonn-Garcia, S., Melero, R., Sorzano, C. O., Carazo, J. M., Medalia, O., & Plückthun, A. (2025). Structural analysis of HER2-trastuzumab complex reveals receptor conformational adaptation Science Advances, 11, eadu9945. https://doi.org/10.1126/sciadv.adu9945
  • Winkelvoß, D., Vukovic, D., Hänny, A.-C., Riermeier, L., Udovcic, A., Kolibius, J., Honegger, A., Mittl, P. R. E., Michel, E., Hansen, S., & Plückthun, A. (2025). Molecular features defining the efficiency of bioPROTACs Communications Biology, 8, 946. https://doi.org/10.1038/s42003-025-08352-w
  • Weiss, F., Kolibius, J., Freitag, P. C., Gantenbein, F., Kipar, A., & Plückthun, A. (2025). Dendritic cell targeting in lymph nodes with modular adapters boosts HAdV5 and HC-HAdV5 tumor vaccination by co-secretion of IL-2v and IL-21 Molecular Therapy. Oncology, 33, 200984. https://doi.org/10.1016/j.omton.2025.200984
  • Kapp, J. N., Verdurmen, W. P. R., Schaefer, J. V., Kopra, K., Nagy-Davidescu, G., Richard, E., Nokin, M.-J., Ernst, P., Tamaskovic, R., Schwill, M., Degen, R., Scholl, C., Santamaría, D., & Plückthun, A. (2025). A nucleotide-independent, pan-RAS-targeted DARPin elicits anti-tumor activity in a multimodal manner Molecular Oncology, 19, 3266–3286. https://doi.org/10.1002/1878-0261.70061
  • Zinsli, L. V., Sobieraj, A. M., Du, J., Ernst, P., Meile, S., Kilcher, S., Iseli, C., Keller, A. P., Dreier, B., Mittl, P. R. E., Plückthun, A., Loessner, M. J., Schmelcher, M., & Dunne, M. (2025). Heterodimerization of staphylococcal phage φ2638A endolysin isoforms and their functional role in bacterial lysis MicroLife, 6, uqaf011. https://doi.org/10.1093/femsml/uqaf011
  • Sequeira, D. P., Suomalainen, M., Freitag, P. C., Plückthun, A., Klingenbrunner, M., Fischer, L., Hemmi, S., Münz, C., Volle, R., & Greber, U. F. (2025). Activated blood-derived human primary T cells support replication of HAdV C5 and virus transmission to polarized human primary epithelial cells Journal of Virology, 99, e0182524. https://doi.org/10.1128/jvi.01825-24
  • Münick, P., Strubel, A., Balourdas, D.-I., Funk, J. S., Mernberger, M., Osterburg, C., Dreier, B., Schaefer, J. V., Tuppi, M., Yüksel, B., Schäfer, B., Knapp, S., Plückthun, A., Stiewe, T., Joerger, A. C., & Dötsch, V. (2025). DARPin-induced reactivation of p53 in HPV-positive cells Nature Structural & Molecular Biology, 32, 790–801. https://doi.org/10.1038/s41594-024-01456-7
  • Tröster, V., Wong, R. P., Börgel, A., Cakilkaya, B., Renz, C., Möckel, M. M., Eifler-Olivi, K., Marinho, J., Reinberg, T., Furler, S., Schaefer, J. V., Plückthun, A., Wolf, E., & Ulrich, H. D. (2025). Custom affinity probes reveal DNA-damage-induced, ssDNA-independent chromatin SUMOylation in budding yeast Cell Reports, 44, 115353. https://doi.org/10.1016/j.celrep.2025.115353

• 2024

  • Münick, P., Zielinski, J., Strubel, A., Gutfreund, N., Dreier, B., Schaefer, J. V., Schäfer, B., Gebel, J., Osterburg, C., Chaikuad, A., Knapp, S., Plückthun, A., & Dötsch, V. (2024). DARPins as a novel tool to detect and degrade p73 Cell Death and Disease, 15, 909. https://doi.org/10.1038/s41419-024-07304-2
  • Henkin, G., Brito, C., Plückthun, A., & Surrey, T. (2024). Preparation of Polarity-Marked Microtubules Using a Plus-End Capping DARPin Bio-Protocol, 14, e5109. https://doi.org/10.21769/BioProtoc.5109
  • Vukovic, D., Winkelvoss, D., Kapp, J. N., Hänny, A.-C., Bürgisser, H., Riermeier, L., Udovcic, A., Tiefenboeck, P., & Plückthun, A. (2024). Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy Scientific Reports, 14, 27153. https://doi.org/10.1038/s41598-024-76224-0
  • Mahran, R., Kapp, J. N., Valtonen, S., Champagne, A., Ning, J., Gillette, W., Stephen, A. G., Hao, F., Plückthun, A., Härmä, H., Pantsar, T., & Kopra, K. (2024). Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96 ACS Chemical Biology, 19, 2152–2164. https://doi.org/10.1021/acschembio.4c00315
  • Zhou, Z., Nguyen, T. L., Li, X., Poujol, C., Berlinska, E., Michelina, S. V., Kapp, J. N., Plückthun, A., Winslow, M. M., Ambrogio, C., Shan, Y., Santamaría, D., & Westover, K. D. (2024). Experimental variables determine the outcome of RAS-RAS interactions Journal of Biological Chemistry, 300, 107859. https://doi.org/10.1016/j.jbc.2024.107859
  • Freitag, P. C., Kolibius, J., Wieboldt, R., Weber, R., Hartmann, K. P., van Gogh, M., Brücher, D., Läubli, H., & Plückthun, A. (2024). DARPin-fused T cell engager for adenovirus-mediated cancer therapy Molecular Therapy. Oncology, 32, 200821. https://doi.org/10.1016/j.omton.2024.200821
  • Auger, S. A., Venkatachalapathy, S., Suazo, K. F. G., Wang, Y., Sarkis, A. W., Bernhagen, K., Justyna, K., Schaefer, J. V., Wollack, J. W., Plückthun, A., Li, L., & Distefano, M. D. (2024). Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry Bioconjugate Chemistry, 35, 922–933. https://doi.org/10.1021/acs.bioconjchem.4c00072

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