Publications of the Plückthun Group

ZORA Publication List

Publications

• 2025

  • Münick, Philipp; Strubel, Alexander; Balourdas, Dimitrios-Ilias; Funk, Julianne S; Mernberger, Marco; Osterburg, Christian; Dreier, Birgit; Schaefer, Jonas V; Tuppi, Marcel; Yüksel, Büşra; Schäfer, Birgit; Knapp, Stefan; Plückthun, Andreas; Stiewe, Thorsten; Joerger, Andreas C; Dötsch, Volker (2025). DARPin-induced reactivation of p53 in HPV-positive cells. Nature Structural & Molecular Biology:Epub ahead of print.

• 2024

  • Münick, Philipp; Zielinski, Jasmin; Strubel, Alexander; Gutfreund, Niklas; Dreier, Birgit; Schaefer, Jonas V; Schäfer, Birgit; Gebel, Jakob; Osterburg, Christian; Chaikuad, Apirat; Knapp, Stefan; Plückthun, Andreas; Dötsch, Volker (2024). DARPins as a novel tool to detect and degrade p73. Cell Death and Disease, 15(12):909.
  • Henkin, Gil; Brito, Cláudia; Plückthun, Andreas; Surrey, Thomas (2024). Preparation of Polarity-Marked Microtubules Using a Plus-End Capping DARPin. Bio-protocol, 14(22):e5109.
  • Vukovic, David; Winkelvoss, Dorothea; Kapp, Jonas N; Hänny, Anna-Carina; Bürgisser, Héloïse; Riermeier, Luca; Udovcic, Anto; Tiefenboeck, Peter; Plückthun, Andreas (2024). Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy. Scientific Reports, 14(1):27153.
  • Mahran, Randa; Kapp, Jonas N; Valtonen, Salla; Champagne, Allison; Ning, Jinying; Gillette, William; Stephen, Andrew G; Hao, Feng; Plückthun, Andreas; Härmä, Harri; Pantsar, Tatu; Kopra, Kari (2024). Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96. ACS Chemical Biology, 19(10):2152-2164.
  • Zhou, Zhiwei; Nguyen, Tra Ly; Li, Xingxiao; Poujol, Christel; Berlinska, Ewa; Michelina, Sandra Vietti; Kapp, Jonas N; Plückthun, Andreas; Winslow, Monte M; Ambrogio, Chiara; Shan, Yibing; Santamaría, David; Westover, Kenneth D (2024). Experimental variables determine the outcome of RAS-RAS interactions. Journal of Biological Chemistry, 300(11):107859.
  • Freitag, Patrick C; Kolibius, Jonas; Wieboldt, Ronja; Weber, Remi; Hartmann, K Patricia; van Gogh, Merel; Brücher, Dominik; Läubli, Heinz; Plückthun, Andreas (2024). DARPin-fused T cell engager for adenovirus-mediated cancer therapy. Molecular therapy. Oncology, 32(3):200821.
  • Auger, Shelby A; Venkatachalapathy, Sneha; Suazo, Kiall Francis G; Wang, Yiao; Sarkis, Alexander W; Bernhagen, Kaitlyn; Justyna, Katarzyna; Schaefer, Jonas V; Wollack, James W; Plückthun, Andreas; Li, Ling; Distefano, Mark D (2024). Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry. Bioconjugate Chemistry, 35(7):922-933.
  • Stark, Yvonne; Menard, Faye; Jeliazkov, Jeliazko R; Ernst, Patrick; Chembath, Anupama; Ashraf, Mohammed; Hine, Anna V; Plückthun, Andreas (2024). Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules. Proceedings of the National Academy of Sciences of the United States of America, 121(27):e2318198121.
  • Houvast, Ruben D; Badr, Nada; March, Taryn; de Muynck, Lysanne D A N; Sier, Vincent Q; Schomann, Timo; Bhairosingh, Shadhvi; Baart, Victor M; Peeters, Judith A H M; van Westen, Gerard J P; Plückthun, Andreas; Burggraaf, Jacobus; Kuppen, Peter J K; Vahrmeijer, Alexander L; Sier, Cornelis F M (2024). Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer. European Journal of Nuclear Medicine and Molecular Imaging, 51(8):2179-2192.
  • Dederer, Verena; Sanz Murillo, Marta; Karasmanis, Eva P; Hatch, Kathryn S; Chatterjee, Deep; Preuss, Franziska; Abdul Azeez, Kamal R; Nguyen, Landon Vu; Galicia, Christian; Dreier, Birgit; Plückthun, Andreas; Versees, Wim; Mathea, Sebastian; Leschziner, Andres E; Reck-Peterson, Samara L; Knapp, Stefan (2024). A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2. Journal of Biological Chemistry, 300(7):107469.
  • Cui, Zhenling; Ayva, Cagla Ergun; Liew, Yi Jin; Guo, Zhong; Mutschler, Roxane; Dreier, Birgit; Fiorito, Maria M; Walden, Patricia; Howard, Christopher B; Ely, Fernanda; Plückthun, Andreas; Pretorius, Carel; Ungerer, Jacobus Pj; Buckle, Ashley M; Alexandrov, Kirill (2024). mRNA Display Pipeline for Protein Biosensor Construction. ACS Sensors, 9(6):2846-2857.
  • Ivanova, Julia R; Benk, Amelie S; Schaefer, Jonas V; Dreier, Birgit; Hermann, Leon O; Plückthun, Andreas; Missirlis, Dimitris; Spatz, Joachim P (2024). Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells. ACS Nano, 18(12):8919-8933.
  • Thalmann, Lars; Martín-González, Natalia; Brücher, Dominik; Plückthun, Andreas; de Pablo, Pedro J; Suomalainen, Maarit; Greber, Urs (2024). Gutless helper-dependent and first generation HAdV5 vectors have similar mechanical properties and common transduction mechanisms. Human Gene Therapy, 35(5-6):163-176.
  • Klinnert, Sarah; Schenkel, Corinne D; Freitag, Patrick C; Günthard, Huldrych F; Plückthun, Andreas; Metzner, Karin J (2024). Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery. Gene Therapy, 31(3-4):74-84.
  • Abdul-Ridha, Alaa; de Zhang, Lazarus A; Betrie, Ashenafi Haileyesus; Deluigi, Mattia; Vaid, Tasneem M; Whitehead, Alice; Zhang, Yifan; Davis, Ben; Harris, Richard; Simmonite, Heather; Hubbard, Roderick E; Gooley, Paul R; Plückthun, Andreas; Bathgate, Ross A D; Chalmers, David K; Scott, Daniel J (2024). Identification of a Novel Subtype-Selective α$_{1B}$-Adrenoceptor Antagonist. ACS Chemical Neuroscience, 15(3):671-684.

• 2023

  • Leka, Oneda; Wu, Yufan; Zanetti, Giulia; Furler, Sven; Reinberg, Thomas; Marinho, Joana; Schaefer, Jonas V; Plückthun, Andreas; Li, Xiaodan; Pirazzini, Marco; Kammerer, Richard A (2023). A DARPin promotes faster onset of botulinum neurotoxin A1 action. Nature Communications, 14(1):8317.
  • Cucuzza, Stefano; Sitnik, Malgorzata; Jurt, Simon; Michel, Erich; Dai, Wenzhao; Müntener, Thomas; Ernst, Patrick; Häussinger, Daniel; Plückthun, Andreas; Zerbe, Oliver (2023). Unexpected dynamics in femtomolar complexes of binding proteins with peptides. Nature Communications, 14(1):7823.
  • Baumann, Christian; Chiang, Wan‐Chin; Valsecchi, Renato; Jurt, Simon; Deluigi, Mattia; Schuster, Matthias; Rosengren, Karl Johan; Plückthun, Andreas; Zerbe, Oliver (2023). Side‐chain dynamics of the α$_{1B}$ ‐adrenergic receptor determined by NMR via methyl relaxation. Protein Science, 32(11):e4801.
  • Strubel, Alexander; Münick, Philipp; Hartmann, Oliver; Chaikuad, Apirat; Dreier, Birgit; Schaefer, Jonas V; Gebel, Jakob; Osterburg, Christian; Tuppi, Marcel; Schäfer, Birgit; Buck, Viktoria; Rosenfeldt, Mathias; Knapp, Stefan; Plückthun, Andreas; Diefenbacher, Markus E; Dötsch, Volker (2023). DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma. Cell Death and Disease, 14(10):674.
  • Hartmann, K Patricia; van Gogh, Merel; Freitag, Patrick C; Kast, Florian; Nagy-Davidescu, Gabriela; Borsig, Lubor; Plückthun, Andreas (2023). FAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment. Molecular Therapy, 31(10):2914-2928.
  • Maliqi, Liridona; Friedrich, Nikolas; Glögl, Matthias; Schmutz, Stefan; Schmidt, Daniel; Rusert, Peter; Schanz, Merle; Zaheri, Maryam; Pasin, Chloé; Niklaus, Cyrille; Foulkes, Caio; Reinberg, Thomas; Dreier, Birgit; Abela, Irene; Peterhoff, David; Hauser, Alexandra; Kouyos, Roger D; Günthard, Huldrych F; van Gils, Marit J; Sanders, Rogier W; Wagner, Ralf; Plückthun, Andreas; Trkola, Alexandra (2023). Assessing immunogenicity barriers of the HIV-1 envelope trimer. NPJ vaccines, 8(1):148.
  • Glögl, Matthias; Friedrich, Nikolas; Cerutti, Gabriele; Lemmin, Thomas; Kwon, Young D; Gorman, Jason; Maliqi, Liridona; Mittl, Peer R E; Hesselman, Maria C; Schmidt, Daniel; Weber, Jacqueline; Foulkes, Caio; Dingens, Adam S; Bylund, Tatsiana; Olia, Adam S; Verardi, Raffaello; Reinberg, Thomas; Baumann, Nicolas S; Rusert, Peter; Dreier, Birgit; Shapiro, Lawrence; Kwong, Peter D; Plückthun, Andreas; Trkola, Alexandra (2023). Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization. Nature Structural & Molecular Biology, 30(9):1323-1336.
  • Shi, Jie; Hauschulte, Kristine; Mikicic, Ivan; Maharjan, Srijana; Arz, Valerie; Strauch, Tina; Heidelberger, Jan B; Schaefer, Jonas V; Dreier, Birgit; Plückthun, Andreas; Beli, Petra; Ulrich, Helle D; Wollscheid, Hans-Peter (2023). Nuclear myosin VI maintains replication fork stability. Nature Communications, 14(1):3787.
  • Freitag, Patrick C; Kaulfuss, Meike; Flühler, Lea; Mietz, Juliane; Weiss, Fabian; Brücher, Dominik; Kolibius, Jonas; Hartmann, K Patricia; Smith, Sheena N; Münz, Christian; Chijioke, Obinna; Plückthun, Andreas (2023). Targeted adenovirus-mediated transduction of human T cells in vitro and in vivo. Molecular Therapy - Methods & Clinical Development, 29:120-132.
  • Gut, Melanie; Dreier, Birgit; Furler, Sven; Sobek, Jens; Plückthun, Andreas; Holland, Jason P (2023). Designed ankyrin repeat proteins for detecting prostate-specific antigen expression in vivo. RSC Chemical Biology, 4(7):494-505.
  • Becker, Lukas; Plückthun, Andreas (2023). DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin. Scientific Reports, 13(1):8048.
  • Blanc, Marine; Lettl, Clara; Guérin, Jérémy; Vieille, Anaïs; Furler, Sven; Briand-Schumacher, Sylvie; Dreier, Birgit; Bergé, Célia; Plückthun, Andreas; Vadon-Le Goff, Sandrine; Fronzes, Rémi; Rousselle, Patricia; Fischer, Wolfgang; Terradot, Laurent (2023). Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. PLoS Pathogens, 19(5):e1011368.
  • Schubert, Rajib; Bae, Taegeun; Simic, Branko; Smith, Sheena N; Park, Seong-Ho; Nagy-Davidescu, Gabriela; Gradinaru, Viviana; Plückthun, Andreas; Hur, Junho K (2023). CRISPR-clear imaging of melanin-rich B16-derived solid tumors. Communications Biology, 6(1):370.
  • Klenk, Christoph; Scrivens, Maria; Niederer, Anina; Shi, Shuying; Mueller, Loretta; Gersz, Elaine; Zauderer, Maurice; Smith, Ernest S; Strohner, Ralf; Plückthun, Andreas (2023). A Vaccinia-based system for directed evolution of GPCRs in mammalian cells. Nature Communications, 14(1):1770.
  • Schellhorn, Sebastian; Brücher, Dominik; Wolff, Natascha A; Schröer, Katrin; Sallard, Erwan; Mese, Kemal; Zhang, Wenli; Ehrke-Schulz, Eric; Thévenod, Frank; Plückthun, Andreas; Ehrhardt, Anja (2023). Targeting Oncolytic Adenoviruses to Cancer Cells Using a Designed Ankyrin Repeat Protein Lipocalin-2 Fusion Protein. Human Gene Therapy, 34(5-6):203-216.
  • Michel, Erich; Cucuzza, Stefano; Mittl, Peer R E; Zerbe, Oliver; Plückthun, Andreas (2023). Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design. Biochemistry, 62(2):318-329.

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