Publications of the Plückthun Group

ZORA Publication List

Publications

• 2022

  • Strubel, Alexander; Münick, Philipp; Chaikuad, Apirat; Dreier, Birgit; Schaefer, Jonas; Gebel, Jakob; Osterburg, Christian; Tuppi, Marcel; Schäfer, Birgit; Knapp, Stefan; Plückthun, Andreas; Dötsch, Volker (2022). Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Cell Death and Differentiation, 29(12):2445-2458.
  • Kiss, Cedric; Gall, Flavio M; Dreier, Birgit; Adams, Michael; Riedl, Rainer; Plückthun, Andreas; Mittl, Peer R E (2022). Structure of a hydrophobic leucinostatin derivative determined by host lattice display. Acta Crystallographica. Section D: Structural Biology, 78(Pt 12):1439-1450.
  • Philippi, Michael; Richter, Christian P; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspötter, Michael; Kurre, Rainer; Holthuis, Joost C M; Garcia, K Christopher; Plückthun, Andreas; Steinhart, Martin; Piehler, Jacob; You, Changjiang (2022). Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt Signalodroplets. Small, 18(50):2203723.
  • Campbell, Benjamin F N; Dittmann, Antje; Dreier, Birgit; Plückthun, Andreas; Tyagarajan, Shiva K (2022). A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology. eLife, 11:e80895.
  • Strittmatter, Tobias; Wang, Yidan; Bertschi, Adrian; Scheller, Leo; Freitag, Patrick C; Ray, Preetam Guha; Stuecheli, Pascal; Schaefer, Jonas V; Reinberg, Thomas; Tsakiris, Dimitrios; Plückthun, Andreas; Ye, Haifeng; Fussenegger, Martin (2022). Programmable DARPin-based receptors for the detection of thrombotic markers. Nature Chemical Biology, 18(10):1125-1134.
  • Zhang, Yi; Wang, Yiao; Uslu, Safak; Venkatachalapathy, Sneha; Rashidian, Mohammad; Schaefer, Jonas V; Plückthun, Andreas; Distefano, Mark D (2022). Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy. International Journal of Molecular Sciences, 23(19):11537.
  • Freitag, Patrick C; Brandl, Fabian; Brücher, Dominik; Weiss, Fabian; Dreier, Birgit; Plückthun, Andreas (2022). Modular Adapters Utilizing Binders of Different Molecular Types Expand Cell-Targeting Options for Adenovirus Gene Delivery. Bioconjugate Chemistry, 33(9):1595-1601.
  • Waltenspühl, Yann; Ehrenmann, Janosch; Vacca, Santiago; Thom, Cristian; Medalia, Ohad; Plückthun, Andreas (2022). Structural basis for the activation and ligand recognition of the human oxytocin receptor. Nature Communications, 13:4153.
  • Kirchhammer, Nicole; Trefny, Marcel P; Natoli, Marina; Brücher, Dominik; Smith, Sheena N; Werner, Franziska; Koch, Victoria; Schreiner, David; Bartoszek, Ewelina; Buchi, Mélanie; Schmid, Markus; Breu, Daniel; Hartmann, K Patricia; Zaytseva, Polina; Thommen, Daniela S; Läubli, Heinz; Böttcher, Jan P; Stanczak, Michal A; Kashyap, Abhishek S; Plückthun, Andreas; Zippelius, Alfred (2022). NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity. Science Translational Medicine, 14(653):eabm9043.
  • Kopra, Kari; Valtonen, Salla; Mahran, Randa; Kapp, Jonas N; Hassan, Nazia; Gillette, William; Dennis, Bryce; Li, Lianbo; Westover, Kenneth D; Plückthun, Andreas; Härmä, Harri (2022). Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability. International Journal of Molecular Sciences, 23(13):7095.
  • Guimaraes Koch, Sofia S; Thorpe, Robin; Kawasaki, Nana; Lefranc, Marie-Paule; Malan, Sarel; Martin, Andrew C R; Mignot, Gilles; Plückthun, Andreas; Rizzi, Menico; Shubat, Stephanie; Weisser, Karin; Balocco, Raffaella (2022). International nonproprietary names for monoclonal antibodies: an evolving nomenclature system. mAbs, 14(1):2075078.
  • Wang, Longlong; Moreira, Etori Aguiar; Kempf, Georg; Miyake, Yasuyuki; Oliveira Esteves, Blandina I; Fahmi, Amal; Schaefer, Jonas V; Dreier, Birgit; Yamauchi, Yohei; Alves, Marco P; Plückthun, Andreas; Matthias, Patrick (2022). Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways. Cell Reports, 39(4):110736.
  • Gisdon, Florian J; Kynast, Josef P; Ayyildiz, Merve; Hine, Anna V; Plückthun, Andreas; Höcker, Birte (2022). Modular peptide binders - development of a predictive technology as alternative for reagent antibodies. Biological Chemistry, 403(5-6):535-543.
  • Schöppe, Jendrik; Ehrenmann, Janosch; Waltenspühl, Yann; Plückthun, Andreas (2022). Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP. Nature Protocols, 17(3):698-726.
  • Qi, Chao; Lavriha, Pia; Mehta, Ved; Khanppnavar, Basavraj; Mohammed, Inayathulla; Li, Yong; Lazaratos, Michalis; Schaefer, Jonas V; Dreier, Birgit; Plückthun, Andreas; Bondar, Ana-Nicoleta; Dessauer, Carmen W; Korkhov, Volodymyr M (2022). Structural basis of adenylyl cyclase 9 activation. Nature Communications, 13:1045.
  • Deluigi, Mattia; Morstein, Lena; Schuster, Matthias; Klenk, Christoph; Merklinger, Lisa; Cridge, Riley R; de Zhang, Lazarus A; Klipp, Alexander; Vacca, Santiago; Vaid, Tasneem M; Mittl, Peer R E; Egloff, Pascal; Eberle, Stefanie A; Zerbe, Oliver; Chalmers, David K; Scott, Daniel J; Plückthun, Andreas (2022). Crystal structure of the α$_{1B}$-adrenergic receptor reveals molecular determinants of selective ligand recognition. Nature Communications, 13(1):382.
  • Matsuda, Shinya; Schaefer, Jonas V; Mii, Yusuke; Hori, Yutaro; Bieli, Dimitri; Taira, Masanori; Plückthun, Andreas; Affolter, Markus (2022). Author Correction: Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc. Nature Communications, 13(1):389.

• 2021

  • Bieri, Manuela; Hendrickx, Rodinde; Bauer, Michael; Yu, Bin; Jetzer, Tania; Dreier, Birgit; Mittl, Peer R E; Sobek, Jens; Plückthun, Andreas; Greber, Urs F; Hemmi, Silvio (2021). The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection. PLoS Pathogens, 17(12):e1010083.
  • Thom, Cristian; Ehrenmann, Janosch; Vacca, Santiago; Waltenspühl, Yann; Schöppe, Jendrik; Medalia, Ohad; Plückthun, Andreas (2021). Structures of neurokinin 1 receptor in complex with Gq and Gs proteins reveal substance P binding mode and unique activation features. Science Advances, 7(50):eabk2872.
  • Bradbury, Andrew R M; Dübel, Stefan; Knappik, Achim; Plückthun, Andreas (2021). Animal- versus in vitro-derived antibodies: avoiding the extremes. mAbs, 13:1950265.
  • Cucuzza, Stefano; Güntert, Peter; Plückthun, Andreas; Zerbe, Oliver (2021). Correction to: An automated iterative approach for protein structure refinement using pseudocontact shifts. Journal of Biomolecular NMR, 75(10-12):429-430.
  • Friedrich, Nikolas; Stiegeler, Emanuel; Glögl, Matthias; Lemmin, Thomas; Hansen, Simon; Kadelka, Claus; Wu, Yufan; Ernst, Patrick; Maliqi, Liridona; Foulkes, Caio; Morin, Mylène; Eroglu, Mustafa; Liechti, Thomas; Ivan, Branislav; Reinberg, Thomas; Schaefer, Jonas V; Karakus, Umut; Ursprung, Stephan; Mann, Axel; Rusert, Peter; Kouyos, Roger D; Robinson, John A; Günthard, Huldrych F; Plückthun, Andreas; Trkola, Alexandra (2021). Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nature Communications, 12:6705.
  • Matsuda, Shinya; Schaefer, Jonas V; Mii, Yusuke; Hori, Yutaro; Bieli, Dimitri; Taira, Masanori; Plückthun, Andreas; Affolter, Markus (2021). Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc. Nature Communications, 12:6435.
  • Mysore, Venkatesh P; Zhou, Zhi-Wei; Ambrogio, Chiara; Li, Lianbo; Kapp, Jonas N; Lu, Chunya; Wang, Qi; Tucker, Maxwell R; Okoro, Jeffrey J; Nagy-Davidescu, Gabriela; Bai, Xiaochen; Plückthun, Andreas; Jänne, Pasi A; Westover, Kenneth D; Shan, Yibing; Shaw, David E (2021). A structural model of a Ras-Raf signalosome. Nature Structural & Molecular Biology, 28(10):847-857.
  • Merten, Hannes; Brandl, Fabian; Zimmermann, Martina; Schaefer, Jonas V; Irpinio, Linda; Sand, Kine M K; Nilsen, Jeannette; Andersen, Jan Terje; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2021). Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling. European Journal of Pharmaceutics and Biopharmaceutics, 167:104-113.
  • Nemergut, Michal; Škrabana, Rostislav; Berta, Martin; Plückthun, Andreas; Sedlák, Erik (2021). Purification of MBP fusion proteins using engineered DARPin affinity matrix. International journal of biological macromolecules, 187:105-112.
  • Stephens, Erin A; Ludwicki, Morgan B; Meksiriporn, Bunyarit; Li, Mingji; Ye, Tianzheng; Monticello, Connor; Forsythe, Katherine J; Kummer, Lutz; Zhou, Pengbo; Plückthun, Andreas; DeLisa, Matthew P (2021). Engineering Single Pan-Specific Ubiquibodies for Targeted Degradation of All Forms of Endogenous ERK Protein Kinase. ACS Synthetic Biology, 10(9):2396-2408.
  • Cucuzza, Stefano; Güntert, Peter; Plückthun, Andreas; Zerbe, Oliver (2021). An automated iterative approach for protein structure refinement using pseudocontact shifts. Journal of Biomolecular NMR, 75(8-9):319-334.
  • Kosareva, Alexandra; Punjabi, Mukesh; Ochoa-Espinosa, Amanda; Xu, Lifen; Schaefer, Jonas V; Dreier, Birgit; Plückthun, Andreas; Kaufmann, Beat A (2021). Designed Ankyrin Repeat Proteins as Novel Binders for Ultrasound Molecular Imaging. Ultrasound in Medicine & Biology, 47(9):2664-2675.
  • Becker, Lukas; Singh Badwal, Jasleen; Brandl, Fabian; Verdurmen, Wouter P R; Plückthun, Andreas (2021). Thermodynamic Stability Is a Strong Predictor for the Delivery of DARPins to the Cytosol via Anthrax Toxin. Pharmaceutics, 13(8):1285.
  • Radom, Filip; Vonrhein, Clemens; Mittl, Peer R E; Plückthun, Andreas (2021). Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 77(Pt 7):192-201.
  • Stüber, Jakob C; Richter, Christian P; Bellón, Junel Sotolongo; Schwill, Martin; König, Iwo; Schuler, Benjamin; Piehler, Jacob; Plückthun, Andreas (2021). Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization. Communications Biology, 4:762.
  • Kast, Florian; Schwill, Martin; Stüber, Jakob C; Pfundstein, Svende; Nagy-Davidescu, Gabriela; Rodríguez, Josep M Monné; Seehusen, Frauke; Richter, Christian P; Honegger, Annemarie; Hartmann, Karen Patricia; Weber, Thomas G; Kroener, Felix; Ernst, Patrick; Piehler, Jacob; Plückthun, Andreas (2021). Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action. Nature Communications, 12:3790.
  • Hartmann, Jessica; Münch, Robert C; Freiling, Ruth-Therese; Schneider, Irene C; Dreier, Birgit; Samukang, Washington; Koch, Joachim; Seeger, Markus A; Plückthun, Andreas; Buchholz, Christian J (2021). Erratum: A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors. Molecular Therapy - Methods & Clinical Development, 21:728.
  • Vulovic, Ivan; Yao, Qing; Park, Young-Jun; Courbet, Alexis; Norris, Andrew; Busch, Florian; Sahasrabuddhe, Aniruddha; Merten, Hannes; Sahtoe, Danny D; Ueda, George; Fallas, Jorge A; Weaver, Sara J; Hsia, Yang; Langan, Robert A; Plückthun, Andreas; Wysocki, Vicki H; Veesler, David; Jensen, Grant J; Baker, David (2021). Generation of ordered protein assemblies using rigid three-body fusion. Proceedings of the National Academy of Sciences of the United States of America, 118(23):e2015037118.
  • Smith, Sheena N; Schubert, Rajib; Simic, Branko; Brücher, Dominik; Schmid, Markus; Kirk, Niels; Freitag, Patrick C; Gradinaru, Viviana; Plückthun, Andreas (2021). The SHREAD gene therapy platform for paracrine delivery improves tumor localization and intratumoral effects of a clinical antibody. Proceedings of the National Academy of Sciences of the United States of America, 118(21):e2017925118.
  • Incaviglia, Ilaria; Frutiger, Andreas; Blickenstorfer, Yves; Treindl, Fridolin; Ammirati, Giulia; Lüchtefeld, Ines; Dreier, Birgit; Plückthun, Andreas; Vörös, Janos; Reichmuth, Andreas M (2021). An Approach for the Real-Time Quantification of Cytosolic Protein-Protein Interactions in Living Cells. ACS Sensors, 6(4):1572-1582.
  • Waltenspühl, Yann; Jeliazkov, Jeliazko R; Kummer, Lutz; Plückthun, Andreas (2021). Directed evolution for high functional production and stability of a challenging G protein-coupled receptor. Scientific Reports, 11:8630.
  • Waltenspühl, Yann; Ehrenmann, Janosch; Klenk, Christoph; Plückthun, Andreas (2021). Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies. Molecules, 26(5):1465.
  • Brücher, Dominik; Kirchhammer, Nicole; Smith, Sheena N; Schumacher, Jatina; Schumacher, Nina; Kolibius, Jonas; Freitag, Patrick C; Schmid, Markus; Weiss, Fabian; Keller, Corina; Grove, Melanie; Greber, Urs F; Zippelius, Alfred; Plückthun, Andreas (2021). iMATCH: an integrated modular assembly system for therapeutic combination high-capacity adenovirus gene therapy. Molecular Therapy - Methods & Clinical Development, 20:572-586.
  • Zhang, Meng; Gui, Miao; Wang, Zi-Fu; Gorgulla, Christoph; Yu, James J; Wu, Hao; Sun, Zhen-Yu J; Klenk, Christoph; Merklinger, Lisa; Morstein, Lena; Hagn, Franz; Plückthun, Andreas; Brown, Alan; Nasr, Mahmoud L; Wagner, Gerhard (2021). Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. Nature Structural & Molecular Biology, 28(3):258-267.
  • Goba, Inguna; Goricanec, David; Schum, Dominik; Hillenbrand, Matthias; Plückthun, Andreas; Hagn, Franz (2021). Probing the Conformation States of Neurotensin Receptor 1 Variants by NMR Site-Directed Methyl Labeling. Chembiochem, 22(1):139-146.
  • Teale, William D; Pasternak, Taras; Dal Bosco, Cristina; Dovzhenko, Alexander; Kratzat, Krystyna; Bildl, Wolfgang; Schwörer, Manuel; Falk, Thorsten; Ruperti, Benadetto; Schaefer, Jonas V; Shahriari, Mojgan; Pilgermayer, Lena; Li, Xugang; Lübben, Florian; Plückthun, Andreas; Schulte, Uwe; Palme, Klaus (2021). Flavonol-mediated stabilization of PIN efflux complexes regulates polar auxin transport. The EMBO Journal, 40:e104416.
  • Deluigi, Mattia; Klipp, Alexander; Klenk, Christoph; Merklinger, Lisa; Eberle, Stefanie A; Morstein, Lena; Heine, Philipp; Mittl, Peer R E; Ernst, Patrick; Kamenecka, Theodore M; He, Yuanjun; Vacca, Santiago; Egloff, Pascal; Honegger, Annemarie; Plückthun, Andreas (2021). Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Science Advances, 7(5):eabe5504.

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