Publications of the Plückthun Group

ZORA Publication List

Publications

• 2021

  • Bieri, Manuela; Hendrickx, Rodinde; Bauer, Michael; Yu, Bin; Jetzer, Tania; Dreier, Birgit; Mittl, Peer R E; Sobek, Jens; Plückthun, Andreas; Greber, Urs F; Hemmi, Silvio (2021). The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection. PLoS Pathogens, 17(12):e1010083.
  • Thom, Cristian; Ehrenmann, Janosch; Vacca, Santiago; Waltenspühl, Yann; Schöppe, Jendrik; Medalia, Ohad; Plückthun, Andreas (2021). Structures of neurokinin 1 receptor in complex with Gq and Gs proteins reveal substance P binding mode and unique activation features. Science Advances, 7(50):eabk2872.
  • Bradbury, Andrew R M; Dübel, Stefan; Knappik, Achim; Plückthun, Andreas (2021). Animal- versus in vitro-derived antibodies: avoiding the extremes. mAbs, 13:1950265.
  • Cucuzza, Stefano; Güntert, Peter; Plückthun, Andreas; Zerbe, Oliver (2021). Correction to: An automated iterative approach for protein structure refinement using pseudocontact shifts. Journal of Biomolecular NMR, 75(10-12):429-430.
  • Friedrich, Nikolas; Stiegeler, Emanuel; Glögl, Matthias; Lemmin, Thomas; Hansen, Simon; Kadelka, Claus; Wu, Yufan; Ernst, Patrick; Maliqi, Liridona; Foulkes, Caio; Morin, Mylène; Eroglu, Mustafa; Liechti, Thomas; Ivan, Branislav; Reinberg, Thomas; Schaefer, Jonas V; Karakus, Umut; Ursprung, Stephan; Mann, Axel; Rusert, Peter; Kouyos, Roger D; Robinson, John A; Günthard, Huldrych F; Plückthun, Andreas; Trkola, Alexandra (2021). Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nature Communications, 12:6705.
  • Matsuda, Shinya; Schaefer, Jonas V; Mii, Yusuke; Hori, Yutaro; Bieli, Dimitri; Taira, Masanori; Plückthun, Andreas; Affolter, Markus (2021). Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc. Nature Communications, 12:6435.
  • Mysore, Venkatesh P; Zhou, Zhi-Wei; Ambrogio, Chiara; Li, Lianbo; Kapp, Jonas N; Lu, Chunya; Wang, Qi; Tucker, Maxwell R; Okoro, Jeffrey J; Nagy-Davidescu, Gabriela; Bai, Xiaochen; Plückthun, Andreas; Jänne, Pasi A; Westover, Kenneth D; Shan, Yibing; Shaw, David E (2021). A structural model of a Ras-Raf signalosome. Nature Structural & Molecular Biology, 28(10):847-857.
  • Merten, Hannes; Brandl, Fabian; Zimmermann, Martina; Schaefer, Jonas V; Irpinio, Linda; Sand, Kine M K; Nilsen, Jeannette; Andersen, Jan Terje; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2021). Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling. European Journal of Pharmaceutics and Biopharmaceutics, 167:104-113.
  • Nemergut, Michal; Škrabana, Rostislav; Berta, Martin; Plückthun, Andreas; Sedlák, Erik (2021). Purification of MBP fusion proteins using engineered DARPin affinity matrix. International journal of biological macromolecules, 187:105-112.
  • Stephens, Erin A; Ludwicki, Morgan B; Meksiriporn, Bunyarit; Li, Mingji; Ye, Tianzheng; Monticello, Connor; Forsythe, Katherine J; Kummer, Lutz; Zhou, Pengbo; Plückthun, Andreas; DeLisa, Matthew P (2021). Engineering Single Pan-Specific Ubiquibodies for Targeted Degradation of All Forms of Endogenous ERK Protein Kinase. ACS Synthetic Biology, 10(9):2396-2408.
  • Cucuzza, Stefano; Güntert, Peter; Plückthun, Andreas; Zerbe, Oliver (2021). An automated iterative approach for protein structure refinement using pseudocontact shifts. Journal of Biomolecular NMR, 75(8-9):319-334.
  • Kosareva, Alexandra; Punjabi, Mukesh; Ochoa-Espinosa, Amanda; Xu, Lifen; Schaefer, Jonas V; Dreier, Birgit; Plückthun, Andreas; Kaufmann, Beat A (2021). Designed Ankyrin Repeat Proteins as Novel Binders for Ultrasound Molecular Imaging. Ultrasound in Medicine & Biology, 47(9):2664-2675.
  • Becker, Lukas; Singh Badwal, Jasleen; Brandl, Fabian; Verdurmen, Wouter P R; Plückthun, Andreas (2021). Thermodynamic Stability Is a Strong Predictor for the Delivery of DARPins to the Cytosol via Anthrax Toxin. Pharmaceutics, 13(8):1285.
  • Radom, Filip; Vonrhein, Clemens; Mittl, Peer R E; Plückthun, Andreas (2021). Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 77(Pt 7):192-201.
  • Stüber, Jakob C; Richter, Christian P; Bellón, Junel Sotolongo; Schwill, Martin; König, Iwo; Schuler, Benjamin; Piehler, Jacob; Plückthun, Andreas (2021). Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization. Communications Biology, 4:762.
  • Kast, Florian; Schwill, Martin; Stüber, Jakob C; Pfundstein, Svende; Nagy-Davidescu, Gabriela; Rodríguez, Josep M Monné; Seehusen, Frauke; Richter, Christian P; Honegger, Annemarie; Hartmann, Karen Patricia; Weber, Thomas G; Kroener, Felix; Ernst, Patrick; Piehler, Jacob; Plückthun, Andreas (2021). Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action. Nature Communications, 12:3790.
  • Hartmann, Jessica; Münch, Robert C; Freiling, Ruth-Therese; Schneider, Irene C; Dreier, Birgit; Samukang, Washington; Koch, Joachim; Seeger, Markus A; Plückthun, Andreas; Buchholz, Christian J (2021). Erratum: A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors. Molecular Therapy - Methods & Clinical Development, 21:728.
  • Vulovic, Ivan; Yao, Qing; Park, Young-Jun; Courbet, Alexis; Norris, Andrew; Busch, Florian; Sahasrabuddhe, Aniruddha; Merten, Hannes; Sahtoe, Danny D; Ueda, George; Fallas, Jorge A; Weaver, Sara J; Hsia, Yang; Langan, Robert A; Plückthun, Andreas; Wysocki, Vicki H; Veesler, David; Jensen, Grant J; Baker, David (2021). Generation of ordered protein assemblies using rigid three-body fusion. Proceedings of the National Academy of Sciences of the United States of America, 118(23):e2015037118.
  • Smith, Sheena N; Schubert, Rajib; Simic, Branko; Brücher, Dominik; Schmid, Markus; Kirk, Niels; Freitag, Patrick C; Gradinaru, Viviana; Plückthun, Andreas (2021). The SHREAD gene therapy platform for paracrine delivery improves tumor localization and intratumoral effects of a clinical antibody. Proceedings of the National Academy of Sciences of the United States of America, 118(21):e2017925118.
  • Incaviglia, Ilaria; Frutiger, Andreas; Blickenstorfer, Yves; Treindl, Fridolin; Ammirati, Giulia; Lüchtefeld, Ines; Dreier, Birgit; Plückthun, Andreas; Vörös, Janos; Reichmuth, Andreas M (2021). An Approach for the Real-Time Quantification of Cytosolic Protein-Protein Interactions in Living Cells. ACS Sensors, 6(4):1572-1582.
  • Waltenspühl, Yann; Jeliazkov, Jeliazko R; Kummer, Lutz; Plückthun, Andreas (2021). Directed evolution for high functional production and stability of a challenging G protein-coupled receptor. Scientific Reports, 11:8630.
  • Waltenspühl, Yann; Ehrenmann, Janosch; Klenk, Christoph; Plückthun, Andreas (2021). Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies. Molecules, 26(5):1465.
  • Brücher, Dominik; Kirchhammer, Nicole; Smith, Sheena N; Schumacher, Jatina; Schumacher, Nina; Kolibius, Jonas; Freitag, Patrick C; Schmid, Markus; Weiss, Fabian; Keller, Corina; Grove, Melanie; Greber, Urs F; Zippelius, Alfred; Plückthun, Andreas (2021). iMATCH: an integrated modular assembly system for therapeutic combination high-capacity adenovirus gene therapy. Molecular Therapy - Methods & Clinical Development, 20:572-586.
  • Zhang, Meng; Gui, Miao; Wang, Zi-Fu; Gorgulla, Christoph; Yu, James J; Wu, Hao; Sun, Zhen-Yu J; Klenk, Christoph; Merklinger, Lisa; Morstein, Lena; Hagn, Franz; Plückthun, Andreas; Brown, Alan; Nasr, Mahmoud L; Wagner, Gerhard (2021). Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. Nature Structural & Molecular Biology, 28(3):258-267.
  • Goba, Inguna; Goricanec, David; Schum, Dominik; Hillenbrand, Matthias; Plückthun, Andreas; Hagn, Franz (2021). Probing the Conformation States of Neurotensin Receptor 1 Variants by NMR Site-Directed Methyl Labeling. Chembiochem, 22(1):139-146.
  • Teale, William D; Pasternak, Taras; Dal Bosco, Cristina; Dovzhenko, Alexander; Kratzat, Krystyna; Bildl, Wolfgang; Schwörer, Manuel; Falk, Thorsten; Ruperti, Benadetto; Schaefer, Jonas V; Shahriari, Mojgan; Pilgermayer, Lena; Li, Xugang; Lübben, Florian; Plückthun, Andreas; Schulte, Uwe; Palme, Klaus (2021). Flavonol-mediated stabilization of PIN efflux complexes regulates polar auxin transport. The EMBO Journal, 40:e104416.
  • Deluigi, Mattia; Klipp, Alexander; Klenk, Christoph; Merklinger, Lisa; Eberle, Stefanie A; Morstein, Lena; Heine, Philipp; Mittl, Peer R E; Ernst, Patrick; Kamenecka, Theodore M; He, Yuanjun; Vacca, Santiago; Egloff, Pascal; Honegger, Annemarie; Plückthun, Andreas (2021). Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Science Advances, 7(5):eabe5504.

• 2020

  • Brandl, Fabian; Busslinger, Sarah; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2020). Optimizing the anti-tumor efficacy of protein-drug conjugates by engineering the molecular size and half-life. Journal of Controlled Release, 327:186-197.
  • Gray, Alison; Bradbury, Andrew R M; Knappik, Achim; Plückthun, Andreas; Borrebaeck, Carl A K; Dübel, Stefan (2020). Animal-free alternatives and the antibody iceberg. Nature Biotechnology, 38(11):1234-1239.
  • Nowak, Kathrin; Rosenthal, Florian; Karlberg, Tobias; Bütepage, Mareike; Thorsell, Ann-Gerd; Dreier, Birgit; Grossmann, Jonas; Sobek, Jens; Imhof, Ralph; Lüscher, Bernhard; Schüler, Herwig; Plückthun, Andreas; Leslie Pedrioli, Deena M; Hottiger, Michael O (2020). Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins. Nature Communications, 11:5199.
  • Schuster, Matthias; Deluigi, Mattia; Pantić, Milica; Vacca, Santiago; Baumann, Christian; Scott, Daniel J; Plückthun, Andreas; Zerbe, Oliver (2020). Optimizing the α1B-adrenergic receptor for solution NMR studies. BBA Biomembranes, 1862(10):183354.
  • Becker, Lukas; Verdurmen, Wouter P R; Plückthun, Andreas (2020). Reengineering anthrax toxin protective antigen for improved receptor-specific protein delivery. BMC Biology, 18(1):100.
  • Gray, Alison C; Bradbury, Andrew R M; Knappik, Achim; Plückthun, Andreas; Borrebaeck, Carl A K; Dübel, Stefan (2020). Animal-derived-antibody generation faces strict reform in accordance with European Union policy on animal use. Nature Methods, 17(8):755-756.
  • Brücher, Dominik; Franc, Vojtech; Smith, Sheena N; Heck, Albert J R; Plückthun, Andreas (2020). Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness. mAbs, 12(1):1792084.
  • Chabloz, Antoine; Schaefer, Jonas V; Kozieradzki, Ivona; Cronin, Shane J F; Strebinger, Daniel; Macaluso, Francesca; Wald, Jiri; Rabbitts, Terence H; Plückthun, Andreas; Marlovits, Thomas C; Penninger, Josef M (2020). Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol. Communications Biology, 3(1):342.
  • Persson, B David; Lenman, Annasara; Frängsmyr, Lars; Schmid, Markus; Ahlm, Clas; Plückthun, Andreas; Jenssen, Håvard; Arnberg, Niklas (2020). Lactoferrin-hexon interactions mediate CAR-independent adenovirus infection of human respiratory cells. Journal of Virology, 94(14):e00542-20.
  • Waltenspühl, Yann; Schöppe, Jendrik; Ehrenmann, Janosch; Kummer, Lutz; Plückthun, Andreas (2020). Crystal structure of the human oxytocin receptor. Science Advances, 6(29):eabb5419.
  • Gray, Alison C; Bradbury, Andrew; Dübel, Stefan; Knappik, Achim; Plückthun, Andreas; Borrebaeck, Carl A K (2020). Reproducibility: bypass animals for antibody production. Nature, 581(7808):262.
  • Andres, Fabio; Schwill, Martin; Boersma, Ykelien L; Plückthun, Andreas (2020). High-Throughput Generation of Bispecific Binding Proteins by Sortase A-Mediated Coupling for Direct Functional Screening in Cell Culture. Molecular Cancer Therapeutics, 19(4):1080-1088.
  • Petrenčáková, Martina; Filandr, František; Hovan, Andrej; Yassaghi, Ghazaleh; Man, Petr; Kožár, Tibor; Schwer, Marc-Simon; Jancura, Daniel; Plückthun, Andreas; Novák, Petr; Miškovský, Pavol; Bánó, Gregor; Sedlák, Erik (2020). Photoinduced damage of AsLOV2 domain is accompanied by increased singlet oxygen production due to flavin dissociation. Scientific Reports, 10:4119.
  • Ernst, Patrick; Zosel, Franziska; Reichen, Christian; Nettels, Daniel; Schuler, Benjamin; Plückthun, Andreas (2020). Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. ACS Chemical Biology, 15(2):457-468.
  • Mittl, Peer Re; Ernst, Patrick; Plückthun, Andreas (2020). Chaperone-assisted structure elucidation with DARPins. Current Opinion in Structural Biology, 60:93-100.
  • Voskuil, Jan L A; Bandrowski, Anita; Begley, C Glenn; Bradbury, Andrew R M; Chalmers, Andrew D; Gomes, Aldrin V; Hardcastle, Travis; Lund-Johansen, Fridtjof; Plückthun, Andreas; Roncador, Giovanna; Solache, Alejandra; Taussig, Michael J; Trimmer, James S; Williams, Cecilia; Goodman, Simon L (2020). The Antibody Society's antibody validation webinar series. mAbs, 12(1):e1794421.

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