Publications of the Plückthun Group

ZORA Publication List

Publications

• 2020

  • Brandl, Fabian; Busslinger, Sarah; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2020). Optimizing the anti-tumor efficacy of protein-drug conjugates by engineering the molecular size and half-life. Journal of Controlled Release, 327:186-197.
  • Gray, Alison; Bradbury, Andrew R M; Knappik, Achim; Plückthun, Andreas; Borrebaeck, Carl A K; Dübel, Stefan (2020). Animal-free alternatives and the antibody iceberg. Nature Biotechnology, 38(11):1234-1239.
  • Nowak, Kathrin; Rosenthal, Florian; Karlberg, Tobias; Bütepage, Mareike; Thorsell, Ann-Gerd; Dreier, Birgit; Grossmann, Jonas; Sobek, Jens; Imhof, Ralph; Lüscher, Bernhard; Schüler, Herwig; Plückthun, Andreas; Leslie Pedrioli, Deena M; Hottiger, Michael O (2020). Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins. Nature Communications, 11:5199.
  • Schuster, Matthias; Deluigi, Mattia; Pantić, Milica; Vacca, Santiago; Baumann, Christian; Scott, Daniel J; Plückthun, Andreas; Zerbe, Oliver (2020). Optimizing the α1B-adrenergic receptor for solution NMR studies. BBA Biomembranes, 1862(10):183354.
  • Becker, Lukas; Verdurmen, Wouter P R; Plückthun, Andreas (2020). Reengineering anthrax toxin protective antigen for improved receptor-specific protein delivery. BMC Biology, 18(1):100.
  • Gray, Alison C; Bradbury, Andrew R M; Knappik, Achim; Plückthun, Andreas; Borrebaeck, Carl A K; Dübel, Stefan (2020). Animal-derived-antibody generation faces strict reform in accordance with European Union policy on animal use. Nature Methods, 17(8):755-756.
  • Brücher, Dominik; Franc, Vojtech; Smith, Sheena N; Heck, Albert J R; Plückthun, Andreas (2020). Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness. mAbs, 12(1):1792084.
  • Chabloz, Antoine; Schaefer, Jonas V; Kozieradzki, Ivona; Cronin, Shane J F; Strebinger, Daniel; Macaluso, Francesca; Wald, Jiri; Rabbitts, Terence H; Plückthun, Andreas; Marlovits, Thomas C; Penninger, Josef M (2020). Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol. Communications Biology, 3(1):342.
  • Persson, B David; Lenman, Annasara; Frängsmyr, Lars; Schmid, Markus; Ahlm, Clas; Plückthun, Andreas; Jenssen, Håvard; Arnberg, Niklas (2020). Lactoferrin-hexon interactions mediate CAR-independent adenovirus infection of human respiratory cells. Journal of Virology, 94(14):e00542-20.
  • Waltenspühl, Yann; Schöppe, Jendrik; Ehrenmann, Janosch; Kummer, Lutz; Plückthun, Andreas (2020). Crystal structure of the human oxytocin receptor. Science Advances, 6(29):eabb5419.
  • Gray, Alison C; Bradbury, Andrew; Dübel, Stefan; Knappik, Achim; Plückthun, Andreas; Borrebaeck, Carl A K (2020). Reproducibility: bypass animals for antibody production. Nature, 581(7808):262.
  • Andres, Fabio; Schwill, Martin; Boersma, Ykelien L; Plückthun, Andreas (2020). High-Throughput Generation of Bispecific Binding Proteins by Sortase A-Mediated Coupling for Direct Functional Screening in Cell Culture. Molecular Cancer Therapeutics, 19(4):1080-1088.
  • Petrenčáková, Martina; Filandr, František; Hovan, Andrej; Yassaghi, Ghazaleh; Man, Petr; Kožár, Tibor; Schwer, Marc-Simon; Jancura, Daniel; Plückthun, Andreas; Novák, Petr; Miškovský, Pavol; Bánó, Gregor; Sedlák, Erik (2020). Photoinduced damage of AsLOV2 domain is accompanied by increased singlet oxygen production due to flavin dissociation. Scientific Reports, 10:4119.
  • Ernst, Patrick; Zosel, Franziska; Reichen, Christian; Nettels, Daniel; Schuler, Benjamin; Plückthun, Andreas (2020). Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. ACS Chemical Biology, 15(2):457-468.
  • Mittl, Peer Re; Ernst, Patrick; Plückthun, Andreas (2020). Chaperone-assisted structure elucidation with DARPins. Current Opinion in Structural Biology, 60:93-100.
  • Voskuil, Jan L A; Bandrowski, Anita; Begley, C Glenn; Bradbury, Andrew R M; Chalmers, Andrew D; Gomes, Aldrin V; Hardcastle, Travis; Lund-Johansen, Fridtjof; Plückthun, Andreas; Roncador, Giovanna; Solache, Alejandra; Taussig, Michael J; Trimmer, James S; Williams, Cecilia; Goodman, Simon L (2020). The Antibody Society's antibody validation webinar series. mAbs, 12(1):e1794421.

• 2019

  • Balakrishnan, Ashwini; Rajan, Anusha; Salter, Alexander I; Kosasih, Paula L; Wu, Qian; Voutsinas, Jenna; Jensen, Michael C; Plückthun, Andreas; Riddell, Stanley R (2019). Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors. Clinical Cancer Research, 25(24):7506-7516.
  • Chernyavska, M; Schmid, M; Freitag, P C; Palacio-Castañeda, V; Piruska, A; Huck, W T S; Plückthun, Andreas; Verdurmen, W P R (2019). Unravelling receptor and RGD motif dependence of retargeted adenoviral vectors using advanced tumor model systems. Scientific Reports, 9(1):18568.
  • Ehrenmann, Janosch; Schöppe, Jendrik; Klenk, Christoph; Plückthun, Andreas (2019). New views into class B GPCRs from the crystal structure of PTH1R. FEBS Journal, 286(24):4852-4860.
  • Ernst, Patrick; Honegger, Annemarie; van der Valk, Floor; Ewald, Christina; Mittl, Peer R E; Plückthun, Andreas (2019). Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts. Scientific Reports, 9:16162.
  • Dunne, Matthew; Rupf, Beatrice; Tala, Marc; Qabrati, Xhem; Ernst, Patrick; Shen, Yang; Sumrall, Eric; Heeb, Laura; Plückthun, Andreas; Loessner, Martin J; Kilcher, Samuel (2019). Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins. Cell Reports, 29(5):1336-1350.e4.
  • Ernst, Patrick; Plückthun, Andreas; Mittl, Peer R E (2019). Structural analysis of biological targets by host:guest crystal lattice engineering. Scientific Reports, 9:15199.
  • Renko, Miha; Fiedler, Marc; Rutherford, Trevor J; Schaefer, Jonas V; Plückthun, Andreas; Bienz, Mariann (2019). Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proceedings of the National Academy of Sciences of the United States of America, 116(42):20977-20983.
  • Brandl, Fabian; Merten, Hannes; Zimmermann, Martina; Béhé, Martin; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2019). Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins. Journal of Controlled Release, 307:379-392.
  • Lorenzer, Cornelia; Streußnig, Sonja; Tot, Emilia; Winkler, Anna-Maria; Merten, Hannes; Brandl, Fabian; Sayers, Edward J; Watson, Peter; Jones, Arwyn T; Zangemeister-Wittke, Uwe; Plückthun, Andreas; Winkler, Johannes (2019). Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing. European Journal of Pharmaceutics and Biopharmaceutics, 141:37-50.
  • Radom, Filip; Paci, Emanuele; Plückthun, Andreas (2019). Computational Modeling of Designed Ankyrin Repeat Protein Complexes with Their Targets. Journal of Molecular Biology, 431(15):2852-2868.
  • Stüber, Jakob C; Kast, Florian; Plückthun, Andreas (2019). High-Throughput Quantification of Surface Protein Internalization and Degradation. ACS Chemical Biology, 14(6):1154-1163.
  • Campanacci, Valérie; Urvoas, Agathe; Cantos-Fernandes, Soraya; Aumont-Nicaise, Magali; Arteni, Ana-Andreea; Velours, Christophe; Valerio-Lepiniec, Marie; Dreier, Birgit; Plückthun, Andreas; Pilon, Antoine; Poüs, Christian; Minard, Philippe; Gigant, Benoît (2019). Insight into microtubule nucleation from tubulin-capping proteins. Proceedings of the National Academy of Sciences of the United States of America, 116(20):9859-9864.
  • Andres, Fabio; Iamele, Luisa; Meyer, Timo; Stüber, Jakob C; Kast, Florian; Gherardi, Ermanno; Niemann, Hartmut H; Plückthun, Andreas (2019). Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking. Journal of Molecular Biology, 431(10):2020-2039.
  • Meksiriporn, Bunyarit; Ludwicki, Morgan B; Stephens, Erin A; Jiang, Allen; Lee, Hyeon-Cheol; Waraho-Zhmayev, Dujduan; Kummer, Lutz; Brandl, Fabian; Plückthun, Andreas; DeLisa, Matthew P (2019). A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins. Nature Communications, 10:1830.
  • Deprey, Kirsten; Becker, Lukas; Kritzer, Joshua; Plückthun, Andreas (2019). Trapped! A Critical Evaluation of Methods for Measuring Total Cellular Uptake versus Cytosolic Localization. Bioconjugate Chemistry, 30(4):1006-1027.
  • Heine, P; Witt, G; Gilardi, A; Gribbon, P; Kummer, L; Plückthun, Andreas (2019). High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor. SLAS Discovery:2472555219837344.
  • Michel, Erich; Plückthun, Andreas; Zerbe, Oliver (2019). Peptide binding affinity redistributes preassembled repeat protein fragments. Biological Chemistry, 400(3):395-404.
  • Tomatis, Pablo Emiliano; Schütz, Marco; Umudumov, Elina; Plückthun, Andreas (2019). Mutations in sigma 70 transcription factor improves expression of functional eukaryotic membrane proteins in Escherichia coli. Scientific Reports, 9(1):2483.
  • Schwill, Martin; Tamaskovic, Rastislav; Gajadhar, Aaron S; Kast, Florian; White, Forest M; Plückthun, Andreas (2019). Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer. Science Signaling, 12(565):1-23.
  • Schöppe, Jendrik; Ehrenmann, Janosch; Klenk, Christoph; Rucktooa, Prakash; Schütz, Marco; Doré, Andrew S; Plückthun, Andreas (2019). Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nature Communications, 10(1):17.
  • Stüber, Jakob C; Plückthun, Andreas (2019). Labeling surface proteins with high specificity: Intrinsic limitations of phosphopantetheinyl transferase systems. PLoS ONE, 14(12):e0226579.
  • Kumar, Abhinav; Plückthun, Andreas (2019). In vivo assembly and large-scale purification of a GPCR - Gα fusion with Gβγ, and characterization of the active complex. PLoS ONE, 14(1):e0210131.

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