Publications of the Plückthun Group

ZORA Publication List

Publications

• 2019

  • Balakrishnan, Ashwini; Rajan, Anusha; Salter, Alexander I; Kosasih, Paula L; Wu, Qian; Voutsinas, Jenna; Jensen, Michael C; Plückthun, Andreas; Riddell, Stanley R (2019). Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors. Clinical Cancer Research, 25(24):7506-7516.
  • Chernyavska, M; Schmid, M; Freitag, P C; Palacio-Castañeda, V; Piruska, A; Huck, W T S; Plückthun, Andreas; Verdurmen, W P R (2019). Unravelling receptor and RGD motif dependence of retargeted adenoviral vectors using advanced tumor model systems. Scientific Reports, 9(1):18568.
  • Ehrenmann, Janosch; Schöppe, Jendrik; Klenk, Christoph; Plückthun, Andreas (2019). New views into class B GPCRs from the crystal structure of PTH1R. FEBS Journal, 286(24):4852-4860.
  • Ernst, Patrick; Honegger, Annemarie; van der Valk, Floor; Ewald, Christina; Mittl, Peer R E; Plückthun, Andreas (2019). Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts. Scientific Reports, 9:16162.
  • Dunne, Matthew; Rupf, Beatrice; Tala, Marc; Qabrati, Xhem; Ernst, Patrick; Shen, Yang; Sumrall, Eric; Heeb, Laura; Plückthun, Andreas; Loessner, Martin J; Kilcher, Samuel (2019). Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins. Cell Reports, 29(5):1336-1350.e4.
  • Ernst, Patrick; Plückthun, Andreas; Mittl, Peer R E (2019). Structural analysis of biological targets by host:guest crystal lattice engineering. Scientific Reports, 9:15199.
  • Renko, Miha; Fiedler, Marc; Rutherford, Trevor J; Schaefer, Jonas V; Plückthun, Andreas; Bienz, Mariann (2019). Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proceedings of the National Academy of Sciences of the United States of America, 116(42):20977-20983.
  • Brandl, Fabian; Merten, Hannes; Zimmermann, Martina; Béhé, Martin; Zangemeister-Wittke, Uwe; Plückthun, Andreas (2019). Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins. Journal of Controlled Release, 307:379-392.
  • Lorenzer, Cornelia; Streußnig, Sonja; Tot, Emilia; Winkler, Anna-Maria; Merten, Hannes; Brandl, Fabian; Sayers, Edward J; Watson, Peter; Jones, Arwyn T; Zangemeister-Wittke, Uwe; Plückthun, Andreas; Winkler, Johannes (2019). Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing. European Journal of Pharmaceutics and Biopharmaceutics, 141:37-50.
  • Radom, Filip; Paci, Emanuele; Plückthun, Andreas (2019). Computational Modeling of Designed Ankyrin Repeat Protein Complexes with Their Targets. Journal of Molecular Biology, 431(15):2852-2868.
  • Stüber, Jakob C; Kast, Florian; Plückthun, Andreas (2019). High-Throughput Quantification of Surface Protein Internalization and Degradation. ACS Chemical Biology, 14(6):1154-1163.
  • Campanacci, Valérie; Urvoas, Agathe; Cantos-Fernandes, Soraya; Aumont-Nicaise, Magali; Arteni, Ana-Andreea; Velours, Christophe; Valerio-Lepiniec, Marie; Dreier, Birgit; Plückthun, Andreas; Pilon, Antoine; Poüs, Christian; Minard, Philippe; Gigant, Benoît (2019). Insight into microtubule nucleation from tubulin-capping proteins. Proceedings of the National Academy of Sciences of the United States of America, 116(20):9859-9864.
  • Andres, Fabio; Iamele, Luisa; Meyer, Timo; Stüber, Jakob C; Kast, Florian; Gherardi, Ermanno; Niemann, Hartmut H; Plückthun, Andreas (2019). Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking. Journal of Molecular Biology, 431(10):2020-2039.
  • Meksiriporn, Bunyarit; Ludwicki, Morgan B; Stephens, Erin A; Jiang, Allen; Lee, Hyeon-Cheol; Waraho-Zhmayev, Dujduan; Kummer, Lutz; Brandl, Fabian; Plückthun, Andreas; DeLisa, Matthew P (2019). A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins. Nature Communications, 10:1830.
  • Deprey, Kirsten; Becker, Lukas; Kritzer, Joshua; Plückthun, Andreas (2019). Trapped! A Critical Evaluation of Methods for Measuring Total Cellular Uptake versus Cytosolic Localization. Bioconjugate Chemistry, 30(4):1006-1027.
  • Heine, P; Witt, G; Gilardi, A; Gribbon, P; Kummer, L; Plückthun, Andreas (2019). High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor. SLAS Discovery:2472555219837344.
  • Michel, Erich; Plückthun, Andreas; Zerbe, Oliver (2019). Peptide binding affinity redistributes preassembled repeat protein fragments. Biological Chemistry, 400(3):395-404.
  • Tomatis, Pablo Emiliano; Schütz, Marco; Umudumov, Elina; Plückthun, Andreas (2019). Mutations in sigma 70 transcription factor improves expression of functional eukaryotic membrane proteins in Escherichia coli. Scientific Reports, 9(1):2483.
  • Schwill, Martin; Tamaskovic, Rastislav; Gajadhar, Aaron S; Kast, Florian; White, Forest M; Plückthun, Andreas (2019). Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer. Science Signaling, 12(565):1-23.
  • Schöppe, Jendrik; Ehrenmann, Janosch; Klenk, Christoph; Rucktooa, Prakash; Schütz, Marco; Doré, Andrew S; Plückthun, Andreas (2019). Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nature Communications, 10(1):17.
  • Stüber, Jakob C; Plückthun, Andreas (2019). Labeling surface proteins with high specificity: Intrinsic limitations of phosphopantetheinyl transferase systems. PLoS ONE, 14(12):e0226579.
  • Kumar, Abhinav; Plückthun, Andreas (2019). In vivo assembly and large-scale purification of a GPCR - Gα fusion with Gβγ, and characterization of the active complex. PLoS ONE, 14(1):e0210131.

• 2018

  • Vigano, M Alessandra; Bieli, Dimitri; Schaefer, Jonas V; Jakob, Roman P; Matsuda, Shinya; Maier, Timm; Plückthun, Andreas; Affolter, Markus (2018). Correction: DARPins recognizing mTFP1 as novel reagents for and protein manipulations (doi:10.1242/bio.036749). Biology Open, 7(12):1.
  • Ehrenmann, Janosch; Schöppe, Jendrik; Klenk, Christoph; Rappas, Mathieu; Kummer, Lutz; Doré, Andrew S; Plückthun, Andreas (2018). High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist. Nature Structural & Molecular Biology, 25(12):1086-1092.
  • Vigano, M Alessandra; Bieli, Dimitri; Schaefer, Jonas V; Jakob, Roman P; Matsuda, Shinya; Maier, Timm; Plückthun, Andreas; Affolter, Markus (2018). DARPins recognize mTFP1 as novel reagents for and protein manipulations. Biology Open, 7(11):036749.
  • ElGamacy, Mohammad; Coles, Murray; Ernst, Patrick; Zhu, Hongbo; Hartmann, Marcus D; Plückthun, Andreas; Lupas, Andrei N (2018). An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture. ACS Synthetic Biology, 7(9):2226-2235.
  • Hartmann, Jessica; Münch, Robert C; Freiling, Ruth-Therese; Schneider, Irene C; Dreier, Birgit; Samukange, Washington; Koch, Joachim; Seeger, Markus A; Plückthun, Andreas; Buchholz, Christian J (2018). A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors. Molecular Therapy - Methods & Clinical Development, 10:128-143.
  • Mikula, Kornelia M; Krumwiede, Luisa; Plückthun, Andreas; Iwaï, Hideo (2018). Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation. Journal of Biomolecular NMR, 71(4):225-235.
  • Wu, Yufan; Honegger, Annemarie; Batyuk, Alexander; Mittl, Peer R E; Plückthun, Andreas (2018). Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions. Journal of Molecular Biology, 430(14):2128-2138.
  • Yen, Hsin-Yung; Hoi, Kin Kuan; Liko, Idlir; Hedger, George; Horrell, Michael R; Song, Wanling; Wu, Di; Heine, Philipp; Warne, Tony; Lee, Yang; Carpenter, Byron; Plückthun, Andreas; Tate, Christopher G; Sansom, Mark S P; Robinson, Carol V (2018). PtdIns(4,5)P stabilizes active states of GPCRs and enhances selectivity of G-protein coupling. Nature, 559(7714):423-427.
  • Radom, Filip; Plückthun, Andreas; Paci, Emanuele (2018). Assessment of ab initio models of protein complexes by molecular dynamics. PLoS Computational Biology, 14(6):e1006182.
  • Schaefer, Jonas V; Sedlák, Erik; Kast, Florian; Nemergut, Michal; Plückthun, Andreas (2018). Modification of the kinetic stability of immunoglobulin G by solvent additives. mAbs, 10(4):607-623.
  • Yong, Kelvin J; Vaid, Tasneem M; Shilling, Patrick J; Wu, Feng-Jie; Williams, Lisa M; Deluigi, Mattia; Plückthun, Andreas; Bathgate, Ross A D; Gooley, Paul R; Scott, Daniel J (2018). Determinants of Ligand Subtype-Selectivity at α-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR. ACS Chemical Biology, 13(4):1090-1102.
  • Stichling, Nicole; Suomalainen, Maarit; Flatt, Justin W; Schmid, Markus; Pacesa, Martin; Hemmi, Silvio; Jungraithmayr, Wolfgang; Maler, Mareike D; Freudenberg, Marina A; Plückthun, Andreas; May, Tobias; Köster, Mario; Fejer, György; Greber, Urs F (2018). Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor. PLoS Pathogens, 14(3):e1006914.
  • Hansen, Simon; Ernst, Patrick; König, Sebastian L B; Reichen, Christian; Ewald, Christina; Nettels, Daniel; Mittl, Peer R E; Schuler, Benjamin; Plückthun, Andreas (2018). Curvature of designed armadillo repeat proteins allows modular peptide binding. Journal of Structural Biology, 201(2):108-117.
  • Schmid, Markus; Ernst, Patrick; Honegger, Annemarie; Suomalainen, Maarit; Zimmermann, Martina; Braun, Lukas; Stauffer, Sarah; Thom, Cristian; Dreier, Birgit; Eibauer, Matthias; Kipar, Anja; Vogel, Viola; Greber, Urs F; Medalia, Ohad; Plückthun, Andreas (2018). Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nature Communications, 9(1):450.
  • Michel, Erich; Plückthun, Andreas; Zerbe, Oliver (2018). Peptide-guided assembly of repeat protein fragments. Angewandte Chemie Internationale Edition, 57(17):4576-4579.

Pagination