Publications of the Plückthun Group

ZORA Publication List

Publications

• 2017

  • Hansen, Simon; Stüber, Jakob C; Ernst, Patrick; Koch, Alexander; Bojar, Daniel; Batyuk, Alexander; Plückthun, Andreas (2017). Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity. Scientific Reports, 7(1):16292.
  • Nemergut, Michal; Žoldák, Gabriel; Schaefer, Jonas V; Kast, Florian; Miškovský, Pavol; Plückthun, Andreas; Sedlák, Erik (2017). Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering. Protein Science, 26(11):2229-2239.
  • Verdurmen, Wouter P R; Mazlami, Marigona; Plückthun, Andreas (2017). A quantitative comparison of cytosolic delivery via different protein uptake systems. Scientific Reports, 7(1):13194.
  • Hansen, Simon; Kiefer, Jonathan D; Madhurantakam, Chaithanya; Mittl, Peer R E; Plückthun, Andreas (2017). Structures of designed armadillo repeat proteins binding to peptides fused to globular domains. Protein Science, 26(10):1942-1952.
  • Wu, Yufan; Batyuk, Alexander; Honegger, Annemarie; Brandl, Fabian; Mittl, Peer R E; Plückthun, Andreas (2017). Rigidly connected multispecific artificial binders with adjustable geometries. Scientific Reports, 7(1):11217.
  • Jost, Christian; Stüber, Jakob C; Honegger, Annemarie; Wu, Yufan; Batyuk, Alexander; Plückthun, Andreas (2017). Rigidity of the extracellular part of HER2: evidence from engineering subdomain interfaces and shared-helix DARPin-DARPin fusions. Protein Science, 26(9):1796-1806.
  • Afroz, Tariq; Hock, Eva-Maria; Ernst, Patrick; Foglieni, Chiara; Jambeau, Melanie; Gilhespy, Larissa A B; Laferriere, Florent; Maniecka, Zuzanna; Plückthun, Andreas; Mittl, Peer; Paganetti, Paolo; Allain, Frédéric H T; Polymenidou, Magdalini (2017). Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. Nature Communications, 8:45.
  • Parren, Paul W H I; Carter, Paul J; Plückthun, Andreas (2017). Changes to International Nonproprietary Names for antibody therapeutics 2017 and beyond: of mice, men and more. mAbs, 9(6):898-906.
  • Ranganathan, Anirudh; Heine, Philipp; Rudling, Axel; Plückthun, Andreas; Kummer, Lutz; Carlsson, Jens (2017). Ligand discovery for a peptide-binding GPCR by Structure-based screening of fragment- and lead-like chemical libraries. ACS Chemical Biology, 12(3):735-745.
  • Anders, Ulrike; Schaefer, Jonas V; Hibti, Fatima-Ezzahra; Frydman, Chiraz; Suckau, Detlev; Plückthun, Andreas; Zenobi, Renato (2017). SPRi-MALDI MS: characterization and identification of a kinase from cell lysate by specific interaction with different designed ankyrin repeat proteins. Analytical and Bioanalytical Chemistry, 409(7):1827-1836.
  • Syafrizayanti; Lueong, Smiths S; Di, Cuixia; Schaefer, Jonas V; Plückthun, Andreas; Hoheisel, Jörg D (2017). Personalised proteome analysis by means of protein microarrays made from individual patient samples. Scientific Reports, 7:39756.
  • Ernst, Patrick; Plückthun, Andreas (2017). Advances in the design and engineering of peptide-binding repeat proteins. Biological Chemistry, 398(1):23-29.
  • Nasr, Mahmoud L; Baptista, Diego; Strauss, Mike; Sun, Zhen-Yu J; Grigoriu, Simina; Huser, Sonja; Plückthun, Andreas; Hagn, Franz; Walz, Thomas; Hogle, James M; Wagner, Gerhard (2017). Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nature Methods, 14(1):49-52.
  • Huber, Sylwia; Casagrande, Fabio; Hug, Melanie N; Wang, Lisha; Heine, Philipp; Kummer, Lutz; Plückthun, Andreas; Hennig, Michael (2017). SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands. PLoS ONE, 12(5):e0175842.
  • Verdurmen, Wouter P R; Mazlami, Marigona; Plückthun, Andreas (2017). A Biotin Ligase-Based Assay for the Quantification of the Cytosolic Delivery of Therapeutic Proteins. Methods in Molecular Biology, 1575:223-236.

• 2016

  • Goricanec, David; Stehle, Ralf; Egloff, Pascal; Grigoriu, Simina; Plückthun, Andreas; Wagner, Gerhard; Hagn, Franz (2016). Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding. Proceedings of the National Academy of Sciences of the United States of America, 113(26):E3629-E3638.
  • Bender, Ruben R; Muth, Anke; Schneider, Irene C; Friedel, Thorsten; Hartmann, Jessica; Plückthun, Andreas; Maisner, Andrea; Buchholz, Christian J (2016). Receptor-targeted nipah virus glycoproteins improve cell-type selective gene delivery and reveal a preference for membrane-proximal cell attachment. PLoS Pathogens, 12(6):e1005641.
  • Batyuk, Alexander; Wu, Yufan; Honegger, Annemarie; Heberling, Matthew M; Plückthun, Andreas (2016). DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography. Journal of Molecular Biology, 428(8):1574-1588.
  • Schütz, Marco; Batyuk, Alexander; Klenk, Christoph; Kummer, Lutz; de Picciotto, Seymour; Gülbakan, Basri; Wu, Yufan; Newby, Gregory A; Zosel, Franziska; Schöppe, Jendrik; Sedlák, Erik; Mittl, Peer R E; Zenobi, Renato; Wittrup, K Dane; Plückthun, Andreas (2016). Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools. Journal of Molecular Biology, 428(6):1272-1289.
  • Hansen, Simon; Tremmel, Dirk; Madhurantakam, Chaithanya; Reichen, Christian; Mittl, Peer R E; Plückthun, Andreas (2016). Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity. Journal of the American Chemical Society, 138(10):3526-3532.
  • Jones, Tim D; Carter, Paul J; Plückthun, Andreas; et al (2016). The INNs and outs of antibody nonproprietary names. mAbs, 8(1):1-9.
  • Reichen, Christian; Madhurantakam, Chaithanya; Hansen, Simon; Grütter, Markus G; Plückthun, Andreas; Mittl, Peer R E (2016). Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects. Acta Crystallographica. Section D: Structural Biology, 72(Pt 1):168-175.
  • Reichen, Christian; Hansen, Simon; Forzani, Cristina; Honegger, Annemarie; Fleishman, Sarel J; Zhou, Ting; Parmeggiani, Fabio; Ernst, Patrick; Madhurantakam, Chaithanya; Ewald, Christina; Mittl, Peer R E; Zerbe, Oliver; Baker, David; Caflisch, Amedeo; Plückthun, Andreas (2016). Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition. Journal of Molecular Biology, 428(22):4467-4489.
  • Ahmad, Shoeb; Pecqueur, Ludovic; Dreier, Birgit; Hamdane, Djemel; Aumont-Nicaise, Magali; Plückthun, Andreas; Knossow, Marcel; Gigant, Benoît (2016). Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin. Scientific Reports, 6:28922.
  • Tamaskovic, Rastislav; Schwill, Martin; Nagy-Davidescu, Gabriela; Jost, Christian; Schaefer, Dagmar C; Verdurmen, Wouter P R; Schaefer, Jonas V; Honegger, Annemarie; Plückthun, Andreas (2016). Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk. Nature Communications, 7:11672.
  • Hanauer, Jan Rh; Gottschlich, Lisa; Riehl, Dennis; Rusch, Tillmann; Koch, Vivian; Friedrich, Katrin; Hutzler, Stefan; Prüfer, Steffen; Friedel, Thorsten; Hanschmann, Kay-Martin; Münch, Robert C; Jost, Christian; Plückthun, Andreas; Cichutek, Klaus; Buchholz, Christian J; Mühlebach, Michael D (2016). Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors. Molecular Therapy : Oncolytics, 3:16003.
  • Schütz, Marco; Schöppe, Jendrik; Sedlák, Erik; Hillenbrand, Matthias; Nagy-Davidescu, Gabriela; Ehrenmann, Janosch; Klenk, Christoph; Egloff, Pascal; Kummer, Lutz; Plückthun, Andreas (2016). Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts. Scientific Reports, 6:21508.
  • Klenk, Christoph; Ehrenmann, Janosch; Schütz, Marco; Plückthun, Andreas (2016). A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution. Scientific Reports, 6:21294.

• 2015

  • Merten, Hannes; Brandl, Fabian; Plückthun, Andreas; Zangemeister-Wittke, Uwe (2015). Antibody-drug conjugates for tumor targeting-novel conjugation chemistries and the promise of non-igg binding proteins. Bioconjugate Chemistry, 26(11):2176-2185.
  • Bradbury, Andrew R M; Plückthun, Andreas (2015). Getting to reproducible antibodies: the rationale for sequenced recombinant characterized reagents. Protein Engineering, Design & Selection, 28(10):303-305.
  • Fleishman, Sarel J; Plückthun, Andreas (2015). Editorial overview: Protein design and evolution-new protein architectures, evolutionary fine-tuning and analysis. Current Opinion in Structural Biology, 33:v-vi.
  • König, Iwo; Zarrine-Afsar, Arash; Aznauryan, Mikayel; Soranno, Andrea; Wunderlich, Bengt; Dingfelder, Fabian; Stüber, Jakob C; Plückthun, Andreas; Nettels, Daniel; Schuler, Benjamin (2015). Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells. Nature Methods, 12(8):773-779.
  • Sedlák, Erik; Schaefer, Jonas V; Marek, Jozef; Gimeson, Peter; Plückthun, Andreas (2015). Advanced analyses of kinetic stabilities of iggs modified by mutations and glycosylation. Protein Science, 24(7):1100-1113.
  • Ewald, Christina; Christen, Martin T; Watson, Randall P; Mihajlovic, Maja; Zhou, Ting; Honegger, Annemarie; Plückthun, Andreas; Caflisch, Amedeo; Zerbe, Oliver (2015). A combined NMR and computational approach to investigate peptide binding to a designed armadillo repeat protein. Journal of Molecular Biology, 427(10):1916-1933.
  • Bradbury, Andrew M; Plückthun, Andreas (2015). Antibodies: validate recombinants once. Nature, 520(7547):295.
  • Egloff, Pascal; Deluigi, Mattia; Heine, Philipp; Balada, Stefanie; Plückthun, Andreas (2015). A cleavable ligand column for the rapid isolation of large quantities of homogeneous and functional neurotensin receptor 1 variants from E. coli. Protein Expression and Purification, 108:106-114.
  • Friedel, Thorsten; Hanisch, Lydia J; Muth, Anke; Honegger, Annemarie; Abken, Hinrich; Plückthun, Andreas; Buchholz, Christian J; Schneider, Irene C (2015). Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv. Protein Engineering, Design & Selection, 28(4):93-106.
  • Oude Blenke, Erik; Klaasse, Gruson; Merten, Hannes; Plückthun, Andreas; Mastrobattista, Enrico; Martin, Nathaniel I (2015). Liposome functionalization with copper-free "click chemistry". Journal of Controlled Release, 202:14-20.
  • Hillenbrand, Matthias; Schori, Christian; Schöppe, Jendrik; Plückthun, Andreas (2015). Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution. Proceedings of the National Academy of Sciences of the United States of America, 112(11):E1181-E1190.
  • Verdurmen, Wouter P R; Luginbühl, Manuel; Honegger, Annemarie; Plückthun, Andreas (2015). Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems. Journal of Controlled Release, 200:13-22.
  • Bradbury, Andrew; Plückthun, Andreas (2015). Reproducibility: Standardize antibodies used in research. Nature, 518(7537):27-29.
  • Goldstein, Robert; Sosabowski, Jane; Livanos, Maria; Leyton, Julius; Vigor, Kim; Bhavsar, Gaurav; Nagy-Davidescu, Gabriela; Rashid, Mohammed; Miranda, Enrique; Yeung, Jenny; Tolner, Berend; Plückthun, Andreas; Mather, Stephen; Meyer, Tim; Chester, Kerry (2015). Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging. European Journal of Nuclear Medicine and Molecular Imaging, 42(2):288-301.
  • Salvati Manni, Livia; Zabara, Alexandru; Osornio, Yazmin M; Schöppe, Jendrik; Batyuk, Alexander; Plückthun, Andreas; Siegel, Jay S; Mezzenga, Raffaele; Landau, Ehud M (2015). Phase behavior of a designed cyclopropyl analogue of monoolein: implications for low-temperature membrane protein crystallization. Angewandte Chemie Internationale Edition, 54(3):1027-1031.
  • Plückthun, Andreas (2015). Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy. Annual Review of Pharmacology and Toxicology, 55:489-511.
  • Münch, Robert C; Muth, Anke; Muik, Alexander; Friedel, Thorsten; Schmatz, Julia; Dreier, Birgit; Trkola, Alexandra; Plückthun, Andreas; Büning, Hildegard; Buchholz, Christian J (2015). Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors. Nature Communications, 6:6246.

Pagination